Cytochrome P450 4A14 (Cyp4a14)

Cyp4a14, also known as Cytochrome P450 Family 4 Subfamily A Member 14, or Arachidonic Acid Cytochrome P450 ω-Hydroxylase, primarily involves itself in the ω-hydroxylation of arachidonic acid. The main metabolic product of this reaction is 20-hydroxyeicosatetraenoic acid (20-HETE), indicating that Cyp4a14 plays a role in fatty acid metabolism and the biosynthesis of eicosanoids. Furthermore, Cyp4a14 is expressed at various locations within the cell, including the apical plasma membrane, cytoplasm, and extracellular space, as well as in membrane-delimited organelles. Current research suggests that the expression of Cyp4a14 is closely related to the onset of hypertension, liver lipid metabolism, intestinal mucosal oxidative stress, and the regeneration of skeletal muscle after injury, and it has become a potential target for drug development and disease treatment research.