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Active Luteinizing Hormone (LH)
ICSH; Lutropin; Interstitial Cell Stimulating Hormone
- Product No.APA441Hu61
- Organism SpeciesHomo sapiens (Human) Same name, Different species.
- Buffer FormulationPBS, pH7.4, containing 5% Trehalose.
- Traits Freeze-dried powder
- Purity> 90%
- Isoelectric Point8.0
- ApplicationsCell culture; Activity Assays.
- Downloadn/a
- UOM 10µg50µg 200µg 1mg 5mg
- FOB
US$ 240
US$ 600
US$ 1200
US$ 3600
US$ 9000
For more details, please contact local distributors!
ACTIVITY TEST
USAGE
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
STORAGE
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
STABILITY
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
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| Magazine | Citations |
| Molecular and Cellular Endocrinology | Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes. PubMed: 19686804 |
| International Journal of Clinical and Experimental Medicine | Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene Ijcem: IJCEM1102004 |
| Biochemical Journal | PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone PubMed: 21108604 |
| Molecular and Cellular Endocrinology | Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes ScienceDirect: S0303720709004043 |
| Asian Journal of Andrology | Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring PubMed: 23314658 |
| EXCLI Journal | Protective role of Hibiscus sabdariffa calyx extract against streptozotocin induced sperm damage in diabetic rats Excli: Source |
| International Journal of Molecular and Cellular Medicine | Central effects of camphor on GnRH and sexual hormones in male rat Pubmed: 24551777 |
| Reproductive Toxicology | Inhibitory effects of mitotane on viability and secretory activity in mouse gonadotroph cell lines Pubmed: 24486453 |
| Urologia internationalis | Effects of Tadalafil on Hemorrhagic Cystitis and Testicular Dysfunction Induced by Cyclophosphamide in Rats Pubmed: 24051982 |
| Journal of Materials Chemistry B | Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering Rsc: Source |
| Electromagnetic Biology and Medicine | The effects of long-term exposure to a 2450 MHz electromagnetic field on growth and pubertal development in female Wistar rats Informahealthcare: Source |
| Academic Sciences | Piper longum hexane fraction induces infertility by modulation of inflammatory mediators and gonadotropin insufficiency in female rats Ijppsjournal: Source |
| Biochemical and Biophysical Research Communications | Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis ScienceDirect: S0006291X14001843 |
| Reproductive Toxicology | Carbamazepine-exposure during gestation and lactation affects pubertal onset and spermatic parameters in male pubertal offspring Pubmed:24126190 |
| Mol Cell Endocrinol. | Quercetin supplementation restores testicular function and augments germ cell survival in the estrogenized rats Pubmed:24316378 |
| Andrologia | Protective effects of Eugenia jambolana extract versus N-acetyl cysteine against cisplatin-induced damage in rat testis Pubmed:24576220 |
| Environmental Research | Perfluorooctane sulfonate effects on the reproductive axis in adult male rats Pubmed:25171141 |
| Genet Mol Biol. | Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility Pubmed:25505846 |
| Turkish Journal of Urology | Apoptosis in testicular tissue of rats after vasectomy: evaluation of eNOS, iNOS immunoreactivities and the effects of ozone therapy Turkishjournalofurology:Source |
| Andrologia | Protective effects of Eugenia jambolana extract versus N‐acetyl cysteine against cisplatin‐induced damage in rat testis PubMed: 24576220 |
| European Journal of Pharmacology | The effect of R-(-)-deprenyl administration on reproductive parameters of rat males PubMed: 25725114 |
| Andrologia | Dose‐and time‐dependent effects of Garcinia kola seed extract on sexual behaviour and reproductive parameters in male Wistar rats PubMed: 26123866 |
| Reprod Toxicol | Simvastatin decreases steroid production in the H295R cell line and decreases steroids and FSH in female rats PubMed: 26476359 |
| Biology of Reproduction | Maternal High-Fat Diet Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring Pubmed:26962114 |
| Andrologia | Dose- and time-dependent effects of Garcinia kola seed extract on sexual behaviour and reproductiveparameters in male Wistar rats. Pubmed:26123866 |
| Int J Mol Sci. | Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice Pubmed:26771609 |
| PLoS Genet. | A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis Pubmed:26977770 |
| Scientific Reports | Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus pubmed:27461373 |
| 33 | Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome. pubmed:28336389 |
| environmental pollution | Environmental exposure to polycyclic aromatic hydrocarbons (PAHs): The correlation with and impact on reproductive hormones in umbilical cord serum. pubmed:27838061 |
| Toxicological Sciences | Exposure of pregnant mice to perfluorobutanesulfonate causes hypothyroxinemia and developmental abnormalities in female offspring pubmed:27803384 |
| Andrologia | Effects of treatment with Hypoxis hemerocallidea extract on sexual behaviour and reproductiveparameters in male rats. pubmed:28000943 |
| Biology of Reproduction | Maternal High-Fat Diet-Induced Loss of Fetal Oocytes Is Associated with Compromised Follicle Growth in Adult Rat Offspring. pubmed:26962114 |
| J Endocrinol. | Impact of uteroplacental insufficiency on postnatal rat male gonad. pubmed:27885054 |
| Int J Pharm. | New gonadotropin-releasing hormone glycolipids with direct antiproliferative activity and gonadotropin-releasing potency. pubmed:28232269 |
| Environmental Science & Technology | Pyrethroid Insecticide Cypermethrin Accelerates Pubertal Onset in Male Mice via Disrupting Hypothalamic-Pituitary-Gonadal Axis pubmed:28731686 |
| Journal of Medicinal Chemistry | Development of New Gonadotropin-Releasing Hormone-Modified Dendrimer Platforms with Direct Antiproliferative and Gonadotropin Releasing Activity pubmed:28958147 |
| Society of Toxicology | Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in LbT2 Mouse Pituitary Cells pubmed:29149324 |
| Reproductive Toxicology | Vitamin D deficiency impairs testicular development and spermatogenesis in mice pubmed:28655646 |
| The Journal of Biological Chemistry. | Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. pubmed:28578315 |
| The Journal of Toxicological Sciences | High sensitivity of testicular function to titanium nanoparticles pubmed:28496042 |
| Journal of Orthopaedic Research | The Combination of icariin and constrained dynamic loading stimulation attenuates bone loss in ovariectomy‐induced osteoporotic mice pubmed:29058779 |
| Anticancer Research | Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapy pubmed:29187457 |
| DARU Journal of Pharmaceutical Sciences | Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway pubmed:29020999 |
| Reproduction. | Effect of controlled ovarian hyperstimulation on puberty and estrus in mice offspring pubmed:28687593 |
| Archives of Toxicology | Atorvastatin decreases steroid production in H295R cells and in major endocrine tissues of male rats Pubmed:29574565 |
| FASEB Journal | Vasorin: a newly identified regulator of ovarian folliculogenesis Pubmed:29259033 |
| Stem Cell Research & Therapy | The role of mesenchymal stem cells in chemotherapy-induced gonadotoxicity Pubmed:30021657 |
| Environmental Pollution | Prenatal exposure to polychlorinated biphenyl and umbilical cord hormones and birth outcomes in an island population Pubmed:29525625 |
| Toxicological Sciences | Impact of Perfluorooctane Sulfonate on Reproductive Ability of Female Mice through Suppression of Estrogen Receptor a-Activated Kisspeptin Neurons 10.1093:toxsci |
| Frontiers in Molecular Neuroscience | Impact of Triclosan on Female Reproduction through Reducing Thyroid Hormones to Suppress Hypothalamic Kisspeptin Neurons in Mice Pubmed:29403355 |
| Biology of Reproduction | Maternal nutrient restriction impairs young adult offspring ovarian signaling resulting in reproductive dysfunction and follicle loss Pubmed:29351580 |
| Journal of Ovarian Research | DHEA-induced ovarian hyperfibrosis is mediated by TGF-β signaling pathway Pubmed:29321035 |
| Medical Science Monitor | Eicosapentaenoic Acid Improves Polycystic Ovary Syndrome in Rats via Sterol Regulatory Element-Binding Protein 1 (SREBP-1)/Toll-Like Receptor 4 (TLR4) … Pubmed:29627845 |
| Human & Experimental Toxicology | Palladium nanoparticle effects on endocrine reproductive system of female rats Pubmed:29405765 |
| A Pex13 knockout in germ cells induces a spermatogenic arrest volltexte:2018/8921/ | |
| Biomedicine & Pharmacotherapy | Crocetin attenuates DHT-induced polycystic ovary syndrome in mice via revising kisspeptin neurons Doi: 10.1016/j.biopha.2018.08.135 |
| 第三军医大学学报 | 基因敲除损伤小鼠睾丸睾酮产生与生精功能 |
| Biological Rhythm Research | Effects of feeding frequency during lactation in primiparous sows on reproduction performance and diurnal rhythm of endocrine profiles at the weaning-to-ovulation … |
| Stem Cells Translational Medicine | Protective Effects of Uncultured Adipose‐Derived Stromal Vascular Fraction on Testicular Injury Induced by Torsion‐Detorsion in Rats Pubmed: 30569668 |
| Journal of Endocrinology | Uterine progesterone signaling is a target for metformin therapy in polycystic ovary syndrome Pubmed: 29535146 |
| Experimental and Therapeutic Medicine | Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary |
| Theriogenology | Organic Zn and Cu interaction impact on sexual behaviour, semen characteristics, hormones and spermatozoal gene expression in bucks (Capra hircus) |
| International Journal of Reproductive Biomedicine | The therapeutic potential of amifostine on cyclophosphamide-induced testicular dysfunction in rats: An experimental study. |
| Andrologia | Sperm parameters quality and reproductive effects of methanolic extract of Alchornea cordifolia leaves on senescent male rats Pubmed: 31353623 |
| Journal of Ovarian Research | Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase Pubmed: 31722718 |
| Chemosphere | Exposure of adult mice to perfluorobutanesulfonate impacts ovarian functions through hypothyroxinemia leading to down-regulation of Akt-mTOR signaling Pubmed: 31809938 |
| Medicina | Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary Morphology Pubmed: 32120970 |
| Chemosphere | Prenatal exposure of female mice to perfluorononanoic acid delays pubertal activation of the reproductive endocrine axis through enhanced hepatic FGF21 … Pubmed: 33131727 |
| BIOLOGICAL RESEARCH | Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance … Pubmed: 33109277 |
| ARCHIVES OF GYNECOLOGY AND OBSTETRICS | MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance Pubmed: 32757043 |
| Mol Med | Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic … Pubmed: 32698821 |
| Antioxidants (Basel) | Composition of Royal Jelly (RJ) and Its Anti-Androgenic Effect on Reproductive Parameters in a Polycystic Ovarian Syndrome (PCOS) Animal Model Pubmed: 32517356 |
| chemosphere | N, N-Dimethylacetamide, an FDA approved excipient, acts post-meiotically to impair spermatogenesis and cause infertility in rats Pubmed: 32447106 |
| Neurotoxicology | Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female mice Pubmed: 32407858 |
| FASEB JOURNAL | Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic … Pubmed: 31648559 |
| BioMed Research International | Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress Pubmed: 32685488 |
| ACS Applied Bio Materials | Evaluation for adverse effects of InP/ZnS quantum dots on the in vitro cultured oocytes of mice |
| Iranian Journal of Basic Medical Sciences | Therapeutic effects of organic zinc on reproductive hormones, insulin resistance and mTOR expression as a novel component in a rat model of PCOS |
| Medical Journal of Cairo University | Hemin Ameliorated Letrozole-Induced Polycystic Ovary Syndrome: A Forward Step for Better Management |
| JOURNAL OF ETHNOPHARMACOLOGY | Zihuai recipe alleviates cyclophosphamide-induced diminished ovarian reserve via suppressing PI3K/AKT-mediated apoptosis 33422655 |
| advanced biomedical research | The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome 33457340 |
| Endocrinology | Diabetes Type 1 Negatively Influences Leydig Cell Function in Rats, Which is Partially Reversible By Insulin Treatment 33507237 |
| JOURNAL OF ETHNOPHARMACOLOGY | BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-¦ÊB pathways in aging mice induced by D-galactose 33508368 |
| Toxicol Appl Pharmacol | Exposure to the bromodomain inhibitor N-methyl pyrrolidone blocks spermatogenesis in a hormonal and non-hormonal fashion 33965371 |
| Nutr Metab | Effects of increasing intake of soybean oil on synthesis of testosterone in Leydig cells 34039393 |
| plants | Tribulus terrestris Efficacy and Safety Concerns in Diabetes and Erectile Dysfunction, Assessed in an Experimental Model 33920217 |
| researchsquare | Lipoamino Acid-Modified GnRH Analogs with Receptor-Mediated Antiproliferative Activity in Prostate and Ovarian Cancer Cells |
| Scientific reports | Regulation of Uterine Function During Estrous Cycle, Anestrus Phase and Pregnancy by Steroids in Red Deer (Cervus elaphus L.) |
| Chronic Exposure to Perfluorohexane Sulfonate Leads to a Reproduction Deficit by Suppressing Hypothalamic Kisspeptin Expression in Mice | |
| JOURNAL OF INHERITED METABOLIC DISEASE | Human and animal fertility studies in cystinosis reveal signs for obstructive azoospermia, a disruptive blood‐testis barrier and a subtherapeutic effect of cysteamine in … 34494673 |
| Free Radical Biology and Medicine | Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion 34610361 |
| Microbiome | Polyamine metabolism links gut microbiota and testicular dysfunction 34758869 |
| J Virol | Zika virus infection in the ovary induces continuously elevated progesterone level and compromises conception in interferon α/β receptor-deficient mice 34730391 |
| Cell Death Dis | METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice 34689175 |
| Theriogenology | Superior effect of broccoli methanolic extract on control of oxidative damage of sperm cryopreservation and reproductive performance in rats: A comparison with … Pubmed:35063921 |
| Nutrients | Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice Pubmed:35057459 |
| Sci Total Environ | Exposure to multiple pyrethroid insecticides affects ovarian follicular development via modifying microRNA expression Pubmed:35276145 |
| Ecotoxicology and Environmental Safety | Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in utero Pubmed:35679725 |
| BMC Veterinary Research | A promising animal model for Polycystic Ovary Syndrome: Borderline Hypertensive Rats |
| Catalog No. | Related products for research use of Homo sapiens (Human) Organism species | Applications (RESEARCH USE ONLY!) |
| APA441Hu62 | Active Luteinizing Hormone (LH) | Cell culture; Activity Assays. |
| APA441Hu01 | Active Luteinizing Hormone (LH) | Cell culture; Activity Assays. |
| EPA441Hu62 | Eukaryotic Luteinizing Hormone (LH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA441Hu01 | Recombinant Luteinizing Hormone (LH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA441Hu02 | Recombinant Luteinizing Hormone (LH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA441Hu61 | Active Luteinizing Hormone (LH) | Cell culture; Activity Assays. |
| APA441Hu02 | Active Luteinizing Hormone (LH) | Cell culture; Activity Assays. |
| CPA441Hu21 | OVA Conjugated Luteinizing Hormone (LH) | Immunogen; SDS-PAGE; WB. |
| PAA441Hu08 | Polyclonal Antibody to Luteinizing Hormone (LH) | WB; IHC; ICC; IP. |
| MAA441Hu21 | Monoclonal Antibody to Luteinizing Hormone (LH) | WB; IHC; ICC; IP. |
| CEA441Hu | ELISA Kit for Luteinizing Hormone (LH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| IEA441Hu | Instant ELISA Kit for Luteinizing Hormone (LH) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| LMA441Hu | Multiplex Assay Kit for Luteinizing Hormone (LH) ,etc. by FLIA (Flow Luminescence Immunoassay) | FLIA Kit for Antigen Detection. |