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Eukaryotic Procollagen I C-Terminal Propeptide (PICP)

P1CP; C-Propeptide Of Type I Procollagen; Procollagen I Carboxy Terminal Propeptide

  • Product No.EPA570Hu61
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceEukaryotic expression
  • Host293F cell
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted, Extracellular matrix
  • Predicted Molecular Mass29.2kDa
  • Accurate Molecular Mass34kDa(Analysis of differences refer to the manual)
  • Residues & TagsAsp1219~Leu1464 with N-terminal His Tag
  • Buffer FormulationPBS, pH7.4, containing 5% Trehalose.
  • Traits Freeze-dried powder
  • Purity> 95%
  • Isoelectric Point5.0
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 280  US$ 700  US$ 1400  US$ 4200  US$ 10500 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in ddH2O to a concentration of 0.1-0.25 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Nutrition Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity ScienceDirect: S0899900709004717
American Heart Journal Serum markers of deranged myocardial collagen turnover: their relation to malignant ventricular arrhythmias in cardioverter-defibrillator recipients with heart failure. PubMed: 23067911
Journal of Hypertension Circulating biomarkers of collagen metabolism in arterial hypertension: relevance of target organ damage Pubmed: 23615327
Pancreatology Cdkn1a is a key mediator of rat pancreatic stellate cell senescence Pubmed: 23719597
The American Journal of Cardiology Relation of burden of myocardial fibrosis to malignant ventricular arrhythmias and outcomes in Fabry disease Pubmed:25073565
PLoS One. An NMR Metabolomic Study on the Effect of Alendronate in Ovariectomized Mice Pubmed:25184758
Journal of Bone and Mineral Research The Anti-Osteoanabolic Function of Sclerostin is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5 Pubmed:25640331
Bone The active role of osteoporosis in the interaction between osteoblasts and bone metastases PubMed: 26057367
J Nutr Biochem Consumption of vitamin D2 PubMed: 25792284
Bibliothekssystem Universität Hamburg Bilaterale Kommunikation zwischen Osteoblasten und Osteoklasten volltexte:2016
Inflammation Research Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathy pubmed:27516211
Heart & Vessels Left ventricular reverse remodeling is not related to biopsy-detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR pubmed:28004175
Scandinavian Journal of Rheumatology The association between insulin-like growth factor 1 (IGF-1), IGF-binding proteins (IGFBPs), and the carboxyterminal propeptide of type I procollagen (PICP) in pre- and postmenopausal women with rheumatoid arthritis. pubmed:27775453
Allergy and Asthma Proceedings Effect of montelukast on markers of airway remodeling in children withasthma. pubmed:27657514
Scandinavian Journal of Rheumatology The association between insulin-like growth factor 1 (IGF-1), IGF-binding proteins (IGFBPs), and the carboxyterminal propeptide of type I procollagen (PICP) in pre- and postmenopausal women with rheumatoid arthritis loi:irhe20
Conditional Mouse Models Support the Role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in Bone Homeostasis ISBN: 978-94-6299-582-6
MOLECULAR MEDICINE REPORTS Endothelial‑to‑mesenchymal transition in human idiopathic dilated cardiomyopathy pubmed:29115553
Pediatrics and Neonatology Age-related changes in biochemical bone profile in thalassemic children pubmed:28967496
Heart and Vessels Left ventricular reverse remodeling is not related to biopsy‑detected extracellular matrix fibrosis and serum markers of fibrosis in dilated cardiomyopathy, regardless of the definition used for LVRR 10.1007/s00380-016-0930-y
Journal of Bone and Mineral Research The Lrp4 R1170Q homozygous knock‐in mouse recapitulates the bone phenotype of sclerosteosis in humans pubmed:28477420
Cytokine 12-month patterns of serum markers of collagen synthesis, transforming growth factor and connective tissue growth factor are similar in new-onset and chronic dilated cardiomyopathy in patients both with and without cardiac fibrosis. pubmed:28460256
Advanced Healthcare Materials Prognostic value of fibrosis-related markers in dilated cardiomyopathy: A link between osteopontin and cardiovascular events. pubmed:29120858
Journal of Bone and Mineral Metabolism Mutations That Alter the Carboxy‐Terminal‐Propeptide Cleavage Site of the Chains of Type I Procollagen Are Associated With a Unique Osteogenesis Imperfecta … Pubmed:29669177
Cardiovascular Journal of Africa Assessment of myocardial fibrosis by late gadolinium enhancement imaging and biomarkers of collagen metabolism in chronic rheumatic mitral regurgitation. Pubmed:29443354
Journal of Cellular Physiology DNA methylation regulates α‐smooth muscle actin expression during cardiac fibroblast differentiation Pubmed: 30362530
International Journal of Chronic Obstructive Pulmonary Disease Altered serum levels of type I collagen turnover indicators accompanied by IL-6 and IL-8 release in stable COPD Pubmed: 30655663
Scientific Reports Low fibrosis biomarker levels predict cardiac resynchronization therapy response Pubmed: 30988339
Bone Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice Pubmed: 31028959
PLoS One Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase Pubmed: 31314788
Bone Mice lacking plastin-3 display a specific defect of cortical bone acquisition Pubmed: 31678489
Journal of Diabetes Research Type 2 Diabetes Mellitus and Chronic Heart Failure with Midrange and Preserved Ejection Fraction: A Focus on Serum Biomarkers of Fibrosis Pubmed: 33224989
JOURNAL OF BONE AND MINERAL RESEARCH Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation Pubmed: 33180356
Microbiome changes in patients with chronic heart failure with preserved ejection fraction correlate with fibrosis markers: Description of a Russian cohort
Ассоциации толщины эпикардиального жира и циркулирующих маркеров фиброза миокарда у пациентов с инфарктом миокарда
Russian Journal of Cardiology Early diagnosis of myocardial fibrosis in patients with epicardial obesity
J Diabetes Res Association between Markers of Fibrosis and Heart Failure Incidence in Patients with Type 2 Diabetes Mellitus 34778465
Clinical, Cosmetic and Investigational Dermatology Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids 34321901
Scandinavian Cardiovascular Journal Dual integrin αvβ3 and αvβ5 blockade attenuates cardiac dysfunction by reducing fibrosis in a rat model of doxorubicin-induced cardiomyopathy 34296634
Eur J Appl Physiol Effects of 8-week increment aerobic exercise program on bone metabolism and body composition in young non-athletes Pubmed:35141785
J. Clin. Med Simple Predictors for Cardiac Fibrosis in Patients with Type 2 Diabetes Mellitus: The Role of Circulating Biomarkers and Pulse Wave Velocity Pubmed:35628969
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
RPA570Hu01 Recombinant Procollagen I C-Terminal Propeptide (PICP) Positive Control; Immunogen; SDS-PAGE; WB.
EPA570Hu61 Eukaryotic Procollagen I C-Terminal Propeptide (PICP) Positive Control; Immunogen; SDS-PAGE; WB.
APA570Hu61 Active Procollagen I C-Terminal Propeptide (PICP) Cell culture; Activity Assays.
CPA570Hu22 OVA Conjugated Procollagen I C-Terminal Propeptide (PICP) Immunogen; SDS-PAGE; WB.
CPA570Hu21 OVA Conjugated Procollagen I C-Terminal Propeptide (PICP) Immunogen; SDS-PAGE; WB.
PAA570Hu01 Polyclonal Antibody to Procollagen I C-Terminal Propeptide (PICP) WB; IHC; ICC; IP.
PAA570Hu08 Polyclonal Antibody to Procollagen I C-Terminal Propeptide (PICP) WB; IHC; ICC; IP.
SEA570Hu ELISA Kit for Procollagen I C-Terminal Propeptide (PICP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA570Hu CLIA Kit for Procollagen I C-Terminal Propeptide (PICP) Chemiluminescent immunoassay for Antigen Detection.
LMA570Hu Multiplex Assay Kit for Procollagen I C-Terminal Propeptide (PICP) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.