Immunological tolerance, as a "double-edged sword", plays a dual role in the autoimmune disease and cancer. Scientists have discovered a new member in the study of anti-cancer families, and that is TIM-3. When part of the patients have resistance to PD-1 inhibitors, TIM-3 inhibitors can effectively overcome this adaptive resistance, and to be the new type of immunotherapy. So, what is TIM-3?T cell immunoglobulin domain and mucin domain-3 (TIM-3) is a class of T cell surface inhibitory molecules, and it can cause T cell death after cancer and virus infection. Richard S. Blumberg team from Harvard Medical School has published the study on Nature. The authors firstly predict tha......2017-04-14

Small molecules include peptides, native small molecules, chemically synthesized small molecules and so on. They are widely used in medicine, pesticides and other fields. The gas chromatography and liquid chromatography are commonly used to quantitatively measure target small molecules. However, there are many disadvantages, such as time-consuming, high cost and so on. Could small molecules be detected by immunoassay kit?All immunoassay kits employ the specific reaction of antigen and antibody. How to produce the antibody specific to small molecule is the key for the preparation of immunoassay kit for small molecule. Because of low molecular weight, simple structure and so on, small mo......2017-04-14

Can chickens lay “gold eggs”? In fairy tales, the chickens can lay “golden eggs”. However, chicken antibodies production platform developed by Cloud-Clone Corp. makes the chicken lay eggs packed with antibodies, which are even more expensive than gold. Antibody is the commonly used tracer in life science research. Its price is 100-1000 time higher than that of gold. Compare with gold price-$44/g, the price of 0.1g antibody is $150 to $300. Usually only one immunized hen's egg contains 0.3g antibody. That is why the chicken raised by Cloud-Clone Corp. can lay “golden eggs”. Rabbit is one of the most commonly used animal for antibody preparation. Although rabbits, same as......2017-04-14

Make the mice anxiety is an important aspect of the preparation of mouse anxiety model, but how to achieve this purpose? Elevated plus-maze test was adopted by the Cloud-Clone Corp.. Elevated plus-maze has a pair of open arms and a pair of close arms. Due to rodents like dark environment, they tend to stay in the close arms. However, rodents will move to open arms because of the characteristic of exploring extraneous environment. In the elevated plus-maze test, the characteristic of exploring extraneous environment and the fear of hung open arms are contradictory, the anxious state of mice were judged by this conflict behavior. Elevated plus-maze is widely used in the study of anxiety.......2017-02-14

Along with the formation of USCN Experimental Animal Inc. and Cloud-Clone Diagnostic Reagents Institute, the company's services have been widened. With the technology platform of institute and the animal resource of animal center, hundreds of animal models, can be provided, including animal models of human disease, tumor transplantation animal models and transgenic animal models. The serum, blood cells, tissues and organs of healthy or diseased animals can be extracted, so the quality control of detection reagentsand hundreds of primary cells can be provided. Several animal experiment services can be offered, such as experimental animals raising, strain purification, group building......2017-02-14

Currently, Cloud-Clone Corp. can provide large numbers of neonatal rat myocardial cells (CSI007Ra01). Primary cardiac myocytes are oval or irregular star, and rhythmically beating. And they can be supplied as the fresh or frozen form with high purity and survival, so they could be used in the cardiovascular, cardiac tissue research and a variety of physiological and biochemical experiments.As we know, cell culture in vitro can supplement the shortage of in vivo test, and it can make the cell function research more operable. However, it is more and more difficult to be convinced of the cell line data. Cell line misidentification and impurity, different genetic phenotype and other factor......2017-02-14