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Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1)

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CCL3-L1; LD78; SCYA3L; SCYA3L1; MIP1AP; MIP1-Alpha-P; Small Inducible Cytokine A3-Like 1; Macrophage Inflammatory Protein 1-Alpha-P; Tonsillar Lymphocyte LD78 Beta

Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1)
CCC A026
HGNC 10628
MGI 98260
PubMed 20095832
UniProt P16619
Wiki CCL3L1

  • 1 is one of several chemokine genes clustered on the q-arm of chromosome 17. Specifically, chemokines attract lymphocytes to sites of infection or damage. This protein binds to several chemokine receptors including chemokine binding protein 2 (CCBP2 or D6) and chemokine (C-C motif) receptor 5 (CCR5).

  • CCR5 is a co-receptor for HIV, and binding of CCL3L1 to CCR5 inhibits HIV entry. Furthermore, the binding causes the receptor to be taken inside the cell by endocytosis, to eventually be reprocessed and re-expressed.The human genome reference assembly contains two full copies of the gene (CCL3L1 and CCL3L3) and an additional partial duplication, which is thought to result in a pseudogene, designated CCL3L2. This record represents the more telomeric full-length gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA026Hu01 Recombinant Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Positive Control; Immunogen; SDS-PAGE; WB.
APA026Hu01 Active Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Cell culture; Activity Assays.
Antibodies PAA026Hu01 Polyclonal Antibody to Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) WB; IHC; ICC; IP.
MAA026Hu22 Monoclonal Antibody to Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) WB; IHC; ICC; IP.
Assay Kits SEA026Hu ELISA Kit for Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA026Hu CLIA Kit for Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA026Mu01 Recombinant Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA026Mu02 Recombinant Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA026Mu01 Polyclonal Antibody to Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) WB; IHC; ICC; IP.
PAA026Mu02 Polyclonal Antibody to Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) WB; IHC; ICC; IP.
Assay Kits SEA026Mu ELISA Kit for Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA026Mu CLIA Kit for Chemokine C-C-Motif Ligand 3 Like Protein 1 (CCL3L1) Chemiluminescent immunoassay for Antigen Detection.
  1. "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q."Nucleic Acids Res. 18:3261-3270(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation."DNA Cell Biol. 9:589-602(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Structures of human genes coding for cytokine LD78 and their expression."Mol. Cell. Biol. 10:3646-3658(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist."Blood 96:1674-1680(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils."Eur. J. Immunol. 31:2170-2178(2001) [PubMed] [Europe PMC] [Abstract]
  8. "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection."Genes Immun. 8:224-231(2007) [PubMed] [Europe PMC] [Abstract]