≡

Insulin Like Growth Factor Binding Protein 1 (IGFBP1)

[Edit]

IBP1; AFBP; IGF-BP25; PP12; Placental Protein 12; Amniotic Fluid Binding Protein; Alpha-Pregnancy-Associated Endometrial Globulin; Growth Hormone Independent-Binding Protein

Insulin Like Growth Factor Binding Protein 1 (IGFBP1)
CCC A052
HGNC 5469
MGI 96436
PubMed 19858071
RGD 2872
UniProt P08833
Wiki IGFBP1

IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family ,a protein with an IGFBP domain and a thyroglobulin type-I domain. IGFBP-1 has been shown to modify the short-term effects of IGFs. Acute and chronic elevations in plasma insulin suppress the hepatic production and the circulating level of IGFBP-1, which, in turn, serve to increase the bioavailability of free IGF-I.
There is growing evidence that IGFBP-1 and the IGF/IGFBP system may form an important link between the development of hyperinsulinemia/insulin resistance and the development of cardiovascular disease. In the circulation, IGFBP-1 may prevent the adverse IGF-mediated remodeling effect on the vasculature.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Hu01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA052Hu02 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA052Hu61 Eukaryotic Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Hu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Hu22 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB,IHC
LAA052Hu81 FITC-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IF.
LAA052Hu71 Biotin-Linked Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC.
PAA052Hu02 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Hu21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB,IHC
MAA052Hu23 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB
MAA052Hu24 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Hu25 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Hu27 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; IF
MAA052Hu26 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits SEA052Hu ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA052Hu CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Mu01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA052Mu02 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Mu01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
PAA052Mu02 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits SEA052Mu ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Ra01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA052Ra61 Eukaryotic Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA052Ra61 Active Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Cell culture; Activity Assays.
Antibodies PAA052Ra01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Ra21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits SEA052Ra ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Po01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Po01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Po21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits SEA052Po ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Bo01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Bo01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
MAA052Bo21 Monoclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits SEA052Bo ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Cp01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Cp01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Ga01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Ga01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA052Fi01 Recombinant Insulin Like Growth Factor Binding Protein 1 (IGFBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA052Fi01 Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 1 (IGFBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Insulin Like Growth Factor Binding Protein 1 (IGFBP1) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)."EMBO J. 7:2417-2423(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, characterization, and expression of a human insulin-like growth factor binding protein."Biochem. Biophys. Res. Commun. 152:1289-1297(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin."Nucleic Acids Res. 16:8711-8711(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA."FEBS Lett. 236:295-302(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors."Mol. Endocrinol. 2:404-411(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein."Mol. Endocrinol. 3:846-851(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1."Biochem. Biophys. Res. Commun. 157:898-907(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7."Genomics 12:497-502(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms."FEBS J. 276:6033-6046(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning."Eur. J. Biochem. 180:259-265(1989) [PubMed] [Europe PMC] [Abstract]
  13. "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions."J. Biol. Chem. 263:14203-14210(1988) [PubMed] [Europe PMC] [Abstract]
  14. "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability."FEBS Lett. 291:264-268(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101."J. Biol. Chem. 268:1125-1131(1993) [PubMed] [Europe PMC] [Abstract]
  16. "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry."J. Biol. Chem. 274:14587-14594(1999) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid."J. Biol. Chem. 280:29812-29819(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins."Proc. Natl. Acad. Sci. U.S.A. 103:13028-13033(2006) [PubMed] [Europe PMC] [Abstract]