Matrix Metalloproteinase 7 (MMP7)
[Edit]MPSL1; MAT; PUMP-1; Matrilysin Uterine; Matrilysin; Matrin; Pump-1 Protease; Uterine Metalloproteinase
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MMP7, also known as Matrilysin, is the smallest member of the MMP-family, it is a zinc-dependent metalloproteinase and is overexpressed in colon cancer and many other human cancers. MMP7 is a secreted matrix metalloproteinase, which contributes to angiogenesis by breaking down basement membranes. Matrix Metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components.
MMP7 is responsible for hydrolyzing proteoglycans and ECM glycoproteins. It is expressed in normal cells, specifically glandular epithelial cells. MMP7, is thought to play an important role in the early steps of tumor progression. Expression of MMP2, MMP7 and MMP11 is greater in pancreatic carcinoma than in normal pancreas.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA102Mu01 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA102Mu02 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA102Mu01 | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. |
| PAA102Mu02 | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA102Mu | ELISA Kit for Matrix Metalloproteinase 7 (MMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA102Mu | CLIA Kit for Matrix Metalloproteinase 7 (MMP7) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA102Ra01 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA102Ra01 | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. |
| MAA102Ra21 | Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA102Ra | ELISA Kit for Matrix Metalloproteinase 7 (MMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA102Ra | CLIA Kit for Matrix Metalloproteinase 7 (MMP7) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA102Bo01 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA102Bo01 | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. |
| MAA102Bo21 | Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA102Bo | ELISA Kit for Matrix Metalloproteinase 7 (MMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA102Bo | CLIA Kit for Matrix Metalloproteinase 7 (MMP7) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Capra hircus; Caprine (Goat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA102Cp01 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA102Cp01 | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. |
| MAA102Cp21 | Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA102Cp | ELISA Kit for Matrix Metalloproteinase 7 (MMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA102Cp | CLIA Kit for Matrix Metalloproteinase 7 (MMP7) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA102Eq01 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA102Eq01 | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. |
| MAA102Eq21 | Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA102Eq | ELISA Kit for Matrix Metalloproteinase 7 (MMP7) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA102Eq | CLIA Kit for Matrix Metalloproteinase 7 (MMP7) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA102Ga01 | Recombinant Matrix Metalloproteinase 7 (MMP7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Matrix Metalloproteinase 7 (MMP7) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Matrix Metalloproteinase 7 (MMP7) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Matrix Metalloproteinase 7 (MMP7) | ELISA Kit Customized Service Offer |
- "The collagenase gene family in humans consists of at least four members."Biochem. J. 253:187-192(1988) [PubMed] [Europe PMC] [Abstract]
- "Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1."Biochem. J. 285:899-905(1992) [PubMed] [Europe PMC] [Abstract]
- "Structure and expression of the human gene for the matrix metalloproteinase matrilysin."J. Biol. Chem. 269:2032-2040(1994) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line."Cancer Res. 50:7758-7764(1990) [PubMed] [Europe PMC] [Abstract]
- "Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members."Biochemistry 28:5327-5334(1989) [PubMed] [Europe PMC] [Abstract]
- "Matrilysin-inhibitor complexes: common themes among metalloproteases."Biochemistry 34:6602-6610(1995) [PubMed] [Europe PMC] [Abstract]