Transforming Growth Factor Beta 1 (TGFb1)
[Edit]TGF-B1; CED; DPD1; LAP; Camurati-Engelmann Disease; Latency-associated peptide
TGF-β is capable of producing a variety of effects and virtually all cell types respond to this factor in some way. The inappropriate presence of active TGF-β1 has been implicated in a variety of pathological conditions Because of the necessity for regulating its activity tightly, TGF-β is secreted by cells in the form of an inactive complex. This complex consists of TGF-β1 associated non-covalently with a protein designated the latency associated peptide (LAP).
TGF-β1 and LAP represent components of a pro-peptide that is cleaved in a post-golgi compartment prior to secretion. LAP and TGF-β1 each consist of a disulfide-linked homodimer and the association of these two components renders TGF-β1 inactive and inaccessible to anti-TGF-β antibodies.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
Organism species: Cavia (Guinea pig )
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Gu01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA124Gu01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
LAA124Gu71 | Biotin-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC. | |
LAA124Gu81 | FITC-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IF. | |
MAA124Gu21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Gu | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Rb01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA124Rb01 | Active Transforming Growth Factor Beta 1 (TGFb1) | Cell culture; Activity Assays. | |
Antibodies | PAA124Rb51 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
MAA124Rb21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Rb | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rhesus monkey (Simian)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Si01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA124Si01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
MAA124Si21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Si | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Ca01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA124Ca01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
MAA124Ca21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Ca | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Po01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA124Po01 | Active Transforming Growth Factor Beta 1 (TGFb1) | Cell culture; Activity Assays. | |
Antibodies | PAA124Po01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC |
LAA124Po71 | Biotin-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC. | |
LAA124Po81 | FITC-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IF. | |
MAA124Po21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Po | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCA124Po | CLIA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Bo01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
APA124Bo01 | Active Transforming Growth Factor Beta 1 (TGFb1) | Cell culture; Activity Assays. | |
Antibodies | PAA124Bo01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
MAA124Bo21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Bo | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
CEA124Bo | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Capra hircus; Caprine (Goat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Recombinant Protein Customized Service Offer |
Antibodies | PAA124Cp01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Transforming Growth Factor Beta 1 (TGFb1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | ELISA Kit Customized Service Offer |
Organism species: Ovis aries; Ovine (Sheep)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Ov01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA124Ov01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
Assay Kits | SEA124Ov | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Eq01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA124Eq01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
MAA124Eq21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Eq | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Ga01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA124Ga02 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAA124Ga01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
LAA124Ga71 | Biotin-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC. | |
LAA124Ga81 | FITC-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IF. | |
MAA124Ga21 | Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
PAA124Ga02 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEA124Ga | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Danio rerio (Zebrafish)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA124Fi01 | Recombinant Transforming Growth Factor Beta 1 (TGFb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA124Fi01 | Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Transforming Growth Factor Beta 1 (TGFb1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) | ELISA Kit Customized Service Offer |
- "Intron-exon structure of the human transforming growth factor-beta precursor gene."Nucleic Acids Res. 15:3188-3189(1987) [PubMed] [Europe PMC] [Abstract]
- "Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells."Nature 316:701-705(1985) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of the gene for human transforming growth factor-beta in Escherichia coli."Tumor Res. 22:41-55(1987)
- "Recombinant human transforming growth factor-beta 1: expression by Chinese hamster ovary cells, isolation, and characterization."Protein Expr. Purif. 4:130-140(1993) [PubMed] [Europe PMC] [Abstract]
- "Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines."J. Biol. Chem. 260:2636-2645(1985) [PubMed] [Europe PMC] [Abstract]
- "Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization."J. Biol. Chem. 263:6407-6415(1988) [PubMed] [Europe PMC] [Abstract]
- "Latent transforming growth factor-beta: structural features and mechanisms of activation."Kidney Int. 51:1376-1382(1997) [PubMed] [Europe PMC] [Abstract]
- "Dermatopontin interacts with transforming growth factor beta and enhances its biological activity."Biochem. J. 337:537-541(1999) [PubMed] [Europe PMC] [Abstract]
- "Differential gene expression of cultured human osteoblasts."J. Cell. Biochem. 83:547-553(2001) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."FASEB J. 20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]
- "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
- "Mechanisms for asporin function and regulation in articular cartilage."J. Biol. Chem. 282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Transforming growth factor beta 1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using Chinese hamster ovary cells."Biochemistry 32:1152-1163(1993) [PubMed] [Europe PMC] [Abstract]
- "Transforming growth factor beta 1: secondary structure as determined by heteronuclear magnetic resonance spectroscopy."Biochemistry 32:1164-1171(1993) [PubMed] [Europe PMC] [Abstract]
- "Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2."Biochemistry 35:8517-8534(1996) [PubMed] [Europe PMC] [Abstract]
- "Association of a polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women."J. Bone Miner. Res. 13:1569-1576(1998) [PubMed] [Europe PMC] [Abstract]
- "Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease."Nat. Genet. 26:19-20(2000) [PubMed] [Europe PMC] [Abstract]
- "Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease."Nat. Genet. 26:273-275(2000) [PubMed] [Europe PMC] [Abstract]
- "A catalog of 106 single-nucleotide polymorphisms (SNPs) and 11 other types of variations in genes for transforming growth factor-beta1 (TGF-beta1) and its signaling pathway."J. Hum. Genet. 47:478-483(2002) [PubMed] [Europe PMC] [Abstract]
- "Transforming growth factor-beta-1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein."J. Biol. Chem. 278:7718-7724(2003) [PubMed] [Europe PMC] [Abstract]
- "A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro."J. Clin. Endocrinol. Metab. 88:3321-3326(2003) [PubMed] [Europe PMC] [Abstract]
- "TGFB1 mutations in four new families with Camurati-Engelmann disease: confirmation of independently arising LAP-domain-specific mutations."Am. J. Med. Genet. 127A:104-107(2004) [PubMed] [Europe PMC] [Abstract]