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Recombinant Transforming Growth Factor Beta 1 (TGFb1)

TGF-B1; CED; DPD1; LAP; Camurati-Engelmann Disease; Latency-associated peptide

  • Product No.RPA124Po01
  • Organism SpeciesSus scrofa; Porcine (Pig) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted, Extracellular matrix
  • Predicted Molecular Mass14.3kDa
  • Accurate Molecular Mass16kDa(Analysis of differences refer to the manual)
  • Residues & TagsAla279~Ser390 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 97%
  • Isoelectric Point8.4
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 152  US$ 380  US$ 760  US$ 2280  US$ 5700 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
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Immunopharmacology and Inflammation Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acid ScienceDirect: S0188440910001049
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revue de medecine veterinaire Increased circulating concentrations of PDGF-BB and TGF-β1 in canine generalised demodicosis Revmedvet: Source
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The Open Respiratory Medicine Journal Biomarkers of Fibroproliferative Healing in Fibrosing Idiopathic Interstitial Pneumonias PubMed: PMC3551240
PLoS ONE A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches Plosone: Source
J Physiol Pharmacol. Fibrogenic response of hepatic stellate cells in ovarectomised rats exposed to ketogenic diet Pubmed: 23568967
international Journal of food and nutritional sciences EVALUATION OF PHYSICO-CHEMICAL PROPERTIES OF COLOSTRUM SUPPLEMENTED DAHI Ijfans: Source
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Int J Clin Exp Pathol Development of a KLD-12 polypeptide/TGF-β1-tissue scaffold promoting the differentiation of esenchymal stem cell into nucleus pulposus-like cells for treatment of intervertebral disc degeneration Ijcep:Source
Am J Physiol Regul Integr Comp Physiol. Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: Role of TGFβ and TNFα Pubmed:25715833
Exp Ther Med. PAR2, IL4R, TGFβ and TNFα in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis Pubmed:Pmc4079423
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Indian J Pharmacol Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin-nicotinamide-induced diabetic nephropathy in rats Pubmed:25538335
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Mol Med Rep NIM811 downregulates transforming growth factor PubMed: 26573209
The Tohoku Journal of Experimental Medicine Salvia Miltiorrhiza Bge.f.alba Ameliorates the Progression of Monocrotaline-Induced Pulmonary Hypertension by Protecting Endothelial Injury in Rats PubMed: 26074502
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Int J Clin Exp Med Uighur medicine abnormal savda munzip (ASMq) suppresses expression of collagen and TGF-β1 with concomitant induce Smad7 in human hypertrophic scar … PubMed: 26309506
Int J Clin Exp Pathol Development of a KLD-12 polypeptide/TGF-β1-tissue scaffold promoting the differentiation of mesenchymal stem cell into nucleus pulposus-like cells for treatment of intervertebral disc degeneration. PubMed: 25972996
International Immunopharmacology Oxymatrine attenuates CCl 4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways Pubmed:27179304
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Molecular Medicine Reports The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway. pubmed:27484042
International Immunopharmacology Amelioration of bleomycin-induced lung fibrosis in rats by valproic acid and butyrate: Role of nuclear factor kappa-B, proinflammatory cytokines and oxidative stress pubmed:27526269
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Therapeutics and Clinical Risk Management Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population. pubmed:27540296
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Ren Fail.  Effect of concomitant administration of coenzyme Q10 with sitagliptin on experimentally induced diabetic nephropathy in rats. pubmed:27841100
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Acta Vet Hung. Imbalance of intestinal immune function in piglets infected by porcine circovirus type 2 during the fetal period. pubmed:28244338
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International Journal of Chemical Studies Studies on quality attributes of skimmed colostrum powder P-ISSN: 2349–8528
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Molecular and Cellular Neuroscience TGF-β1 enhances phagocytic removal of neuron debris and neuronal survival by olfactory ensheathing cells via integrin/MFG-E8 signaling pathway 10.1016/j.mcn.2017.08.006
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Journal of Controlled Release Nose-to-brain delivery of insulin enhanced by a nanogel carrier Pubmed:29196041
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Communications Biology Activated hepatic stellate cells promote epithelial-to-mesenchymal transition in hepatocellular carcinoma through transglutaminase 2-induced pseudohypoxia
Bulletin of Experimental Biology and Medicine Expression of Hif-1α, Nf-κb, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1α, Erythropoietin, VEGF, TGF-β, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia. Corticosterone in … Pubmed: 30353332
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International Journal of Peptide Research and Therapeutics ANP/NPRA Inhibits Epithelial-Mesenchymal Transition of Airway by Targeting Smad3 in Asthma
Journal of Neuroinflammation Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease Pubmed: 30777084
Biochimie Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: reduction of PPARα Pubmed: 30890453
Molecular Medicine Reports Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction Pubmed: 30816496
International Journal of Nanomedicine Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes Pubmed: 30863067
Behavioural Brain Research THE ROLE OF ANTI-INFLAMMATORY CYTOKINES IN MEMORY PROCESSING IN A HEALTHY BRAIN
International Journal of Ophthalmology A novel xeno-free culture system for human retinal pigment epithelium cells Pubmed: 31024807
Open Access Macedonian Journal of Medical Sciences Low Degree Hyaluronic Acid Crosslinking Inducing the Release of TGF-Β1 in Conditioned Medium of Wharton's Jelly-Derived Stem Cells
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Food & Function Network pharmacology oriented study reveals inflammatory state-dependent dietary supplement hepatotoxicity responses in normal and diseased rats Pubmed: 31140472
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Acta Histochemica Hyperoside protects against heart failure-induced liver fibrosis in rats Pubmed: 31353051
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Scientific Reports Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus Pubmed: 31578381
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Experimental Cell Research CD4+ CD25+ Tregs as dependent factor in the course of bleomycin-induced pulmonary fibrosis in mice Pubmed: 31678213
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Antioxidants Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant's Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory … Pubmed:35204215
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Vaccines Age-Dependent Dynamics of Maternally Derived Antibodies (MDAs) and Understanding MDA-Mediated Immune Tolerance in Foot-and-Mouth Disease-Vaccinated … Pubmed:35632433
Biomaterials Advances Human adipose-derived stem cell-loaded small intestinal submucosa as a bioactive wound dressing for the treatment of diabetic wounds in rats
Catalog No. Related products for research use of Sus scrofa; Porcine (Pig) Organism species Applications (RESEARCH USE ONLY!)
APA124Po01 Active Transforming Growth Factor Beta 1 (TGFb1) Cell culture; Activity Assays.
RPA124Po01 Recombinant Transforming Growth Factor Beta 1 (TGFb1) Positive Control; Immunogen; SDS-PAGE; WB.
PAA124Po01 Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) WB; IHC
LAA124Po71 Biotin-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) WB; IHC; ICC.
LAA124Po81 FITC-Linked Polyclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) WB; IHC; ICC; IF.
MAA124Po21 Monoclonal Antibody to Transforming Growth Factor Beta 1 (TGFb1) WB; IHC; ICC; IP.
SEA124Po ELISA Kit for Transforming Growth Factor Beta 1 (TGFb1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA124Po CLIA Kit for Transforming Growth Factor Beta 1 (TGFb1) Chemiluminescent immunoassay for Antigen Detection.
LMA124Po Multiplex Assay Kit for Transforming Growth Factor Beta 1 (TGFb1) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.