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Prostate Specific Antigen (PSA)

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KLK3; APS; KLK2A1; HK3; KLKB1; Seminin; Prostate Specific Antigen; Kallikrein-Related Peptidase 3; Semenogelase, g-Seminoprotein; P-30 Antigen; Plasma kallikrein

Prostate Specific Antigen (PSA)
CCC A151
HGNC 6364
MGI 892021
PubMed 17177156
RGD 2971
UniProt P07288
Wiki KLK3

Human prostate-specific antigen (APS) is a kallikrein-like protease present in seminal plasma. It is a single-chain glycoprotein with a molecular mass of about 33 kD that may function normally in the liquefaction of seminal coagulum. Radioimmunoassay of serum levels of this antigen (called PSA in the clinical setting) is useful in the diagnosis and monitoring of prostatic carcinoma. The full-length KLK3 protein contains 261 amino acids. It has a putative signal peptide, followed by a short activating peptide and the protease domain, which includes the catalytic triad of his65, asp120, and ser213. RT-PCR of 35 adult and fetal tissues detected highest expression in prostate. Expression was weak in colon, mammary gland, and parotid, and little to no expression was detected in other tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA151Hu01 Recombinant Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
CPA151Hu21 OVA Conjugated Prostate Specific Antigen (PSA) Immunogen; SDS-PAGE; WB.
EPA151Hu61 Eukaryotic Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
APA151Hu61 Active Prostate Specific Antigen (PSA) Cell culture; Activity Assays.
APA151Hu01 Active Prostate Specific Antigen (PSA) Cell culture; Activity Assays.
RPA151Hu02 Recombinant Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA151Hu01 Polyclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
MAA151Hu22 Monoclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
PAA151Hu02 Polyclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
MAA151Hu23 Monoclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
MAA151Hu24 Monoclonal Antibody to Prostate Specific Antigen (PSA) WB
MAA151Hu21 Monoclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
Assay Kits SEA151Hu ELISA Kit for Prostate Specific Antigen (PSA) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA151Hu CLIA Kit for Prostate Specific Antigen (PSA) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA151Mu01 Recombinant Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA151Mu02 Recombinant Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA151Mu01 Polyclonal Antibody to Prostate Specific Antigen (PSA) WB
PAA151Mu02 Polyclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
Assay Kits SEA151Mu ELISA Kit for Prostate Specific Antigen (PSA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA151Ra01 Recombinant Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA151Ra01 Polyclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
MAA151Ra21 Monoclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
Assay Kits SEA151Ra ELISA Kit for Prostate Specific Antigen (PSA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA151Si01 Recombinant Prostate Specific Antigen (PSA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA151Si01 Polyclonal Antibody to Prostate Specific Antigen (PSA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Prostate Specific Antigen (PSA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostate Specific Antigen (PSA) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human prostate specific antigen cDNA."FEBS Lett. 214:317-322(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1."Nucleic Acids Res. 17:2137-2137(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic sequence of human prostate specific antigen (PSA)."Nucleic Acids Res. 17:3981-3981(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the gene for prostate-specific antigen, a human glandular kallikrein."Biochem. Biophys. Res. Commun. 161:1151-1159(1989) [PubMed] [Europe PMC] [Abstract]
  5. "cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes."Biochem. Biophys. Res. Commun. 160:903-910(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene."Biochem. Biophys. Res. Commun. 159:95-102(1989) [PubMed] [Europe PMC] [Abstract]
  7. "A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue."Urology 47:795-800(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors."Cancer Res. 54:6344-6347(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence."Nucleic Acids Res. 16:6226-6226(1988) [PubMed] [Europe PMC] [Abstract]
  13. "Human prostate-specific antigen: structural and functional similarity with serine proteases."Proc. Natl. Acad. Sci. U.S.A. 83:3166-3170(1986) [PubMed] [Europe PMC] [Abstract]
  14. "Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma."Eur. J. Biochem. 170:111-120(1987) [PubMed] [Europe PMC] [Abstract]
  15. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring."Mol. Cell. Proteomics 12:2761-2773(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen."Thromb. Res. 64:309-320(1991) [PubMed] [Europe PMC] [Abstract]
  18. "A structural model for the prostate disease marker, human prostate-specific antigen."Protein Sci. 3:2033-2044(1994) [PubMed] [Europe PMC] [Abstract]
  19. "Substrate specificity of prostate-specific antigen (PSA)."Chem. Biol. 5:475-488(1998) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody."J. Mol. Biol. 376:1021-1033(2008) [PubMed] [Europe PMC] [Abstract]