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Hexosaminidase A Alpha (HEXa)

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TSD; Hex-A; Tay Sachs Disease; GM2 Gangliosidosis; Beta-Hexosaminidase Subunit Alpha; Beta-N-Acetylhexosaminidase Subunit Alpha; N-Acetyl-Beta-Glucosaminidase Alpha

Hexosaminidase A Alpha (HEXa)
CCC A195
HGNC 4878
MGI 96073
PubMed 9643539
RGD 2792
UniProt P06865
Wiki HEXA

Hexosaminidase A (alpha polypeptide), is an enzyme that is encoded by the HEXA gene.β-hexosaminidase occurs as two major isozymes: hexosaminidase A and hexosaminidase B. Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines. Hexosaminidase A is a heterodimer composed of an alpha and beta subunit. The alpha subunit is encoded by the HEXA gene while the beta subunit is encoded by the HEXB gene. Gene mutations in the gene encoding the beta subunit (HEXB) often result in Sandhoff disease; whereas, mutations in the gene encoding the alpha subunit (HEXA, this gene) decrease the hydrolysis of GM2 gangliosides, which is the main cause of Tay-Sachs disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA195Hu01 Recombinant Hexosaminidase A Alpha (HEXa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA195Hu01 Polyclonal Antibody to Hexosaminidase A Alpha (HEXa) WB; IHC; ICC; IP.
MAA195Hu22 Monoclonal Antibody to Hexosaminidase A Alpha (HEXa) WB; IHC; ICC; IP.
Assay Kits SEA195Hu ELISA Kit for Hexosaminidase A Alpha (HEXa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA195Mu01 Recombinant Hexosaminidase A Alpha (HEXa) Positive Control; Immunogen; SDS-PAGE; WB.
RPA195Mu02 Recombinant Hexosaminidase A Alpha (HEXa) Positive Control; Immunogen; SDS-PAGE; WB.
APA195Mu01 Active Hexosaminidase A Alpha (HEXa) Cell culture; Activity Assays.
Antibodies PAA195Mu01 Polyclonal Antibody to Hexosaminidase A Alpha (HEXa) WB; IHC; ICC; IP.
PAA195Mu02 Polyclonal Antibody to Hexosaminidase A Alpha (HEXa) WB; IHC; ICC; IP.
Assay Kits SEA195Mu ELISA Kit for Hexosaminidase A Alpha (HEXa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hexosaminidase A Alpha (HEXa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hexosaminidase A Alpha (HEXa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hexosaminidase A Alpha (HEXa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hexosaminidase A Alpha (HEXa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hexosaminidase A Alpha (HEXa) ELISA Kit Customized Service Offer
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