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Growth Arrest Specific Protein 6 (GAS6)

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AXLLG; AXSF; AXL Stimulatory Factor; AXL receptor tyrosine kinase ligand

Growth Arrest Specific Protein 6 (GAS6)
CCC A204
HGNC 4168
MGI 95660
PubMed 17897008
RGD 61913
UniProt Q14393
Wiki GAS6
Growth arrest-specific 6 is similar to the Protein S with the same domain organization and 43% amino acid identity. GAS6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation. The gene is expressed as an abundant 2.6-kb mRNA in starved cells but decreases significantly upon stimulation of cells with serum or fibroblast growth factor. A human homolog was isolated from HeLa cells and was predicted to encode a 678-amino acid protein with 81% identity to the mouse protein and 44% identity to human protein S, a vitamin K-dependent negative coregulator in the blood coagulation pathway. Regions of greatest similarity between Gas6 and protein S occur in a gamma carboxylated glutamic acid-rich domain and in 4 EGF-like domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA204Hu01 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA204Hu02 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
APA204Hu01 Active Growth Arrest Specific Protein 6 (GAS6) Cell culture; Activity Assays.
RPA204Hu03 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA204Hu01 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
MAA204Hu22 Monoclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
LAA204Hu71 Biotin-Linked Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC.
PAA204Hu02 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
PAA204Hu03 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
Assay Kits SEA204Hu ELISA Kit for Growth Arrest Specific Protein 6 (GAS6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA204Mu01 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA204Mu02 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA204Mu01 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
PAA204Mu02 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
Assay Kits SEA204Mu ELISA Kit for Growth Arrest Specific Protein 6 (GAS6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA204Ra01 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA204Ra02 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
RPA204Ra03 Recombinant Growth Arrest Specific Protein 6 (GAS6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA204Ra01 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
PAA204Ra02 Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) WB; IHC; ICC; IP.
Assay Kits SEA204Ra ELISA Kit for Growth Arrest Specific Protein 6 (GAS6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade."Mol. Cell. Biol. 13:4976-4985(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke."Hum. Mutat. 23:506-512(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6."Nature 373:623-626(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases." Cell 80:661-670(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6."FEBS Lett. 415:56-58(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases."J. Biol. Chem. 271:30022-30027(1996) [PubMed] [Europe PMC] [Abstract]
  10. "The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation."FEBS Lett. 415:59-63(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Acidification prevents endothelial cell apoptosis by Axl activation."Circ. Res. 91:E4-12(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development."Blood 113:2470-2477(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl."J. Biol. Chem. 271:9785-9789(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for Gas6-Axl signalling."EMBO J. 25:80-87(2006) [PubMed] [Europe PMC] [Abstract]