Urocortin (UCN)

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UI; UROC; Urocortin 1; UCN1

Urocortin (UCN)

Urocortin is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA231Hu01 Recombinant Urocortin (UCN) Positive Control; Immunogen; SDS-PAGE; WB.
CPA231Hu21 OVA Conjugated Urocortin (UCN) Immunogen; SDS-PAGE; WB.
RPA231Hu02 Recombinant Urocortin (UCN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA231Hu01 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
MAA231Hu22 Monoclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
LAA231Hu71 Biotin-Linked Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC.
PAA231Hu08 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
Assay Kits SEA231Hu ELISA Kit for Urocortin (UCN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA231Mu01 Recombinant Urocortin (UCN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA231Mu02 Recombinant Urocortin (UCN) Positive Control; Immunogen; SDS-PAGE; WB.
CPA231Mu21 OVA Conjugated Urocortin (UCN) Immunogen; SDS-PAGE; WB.
Antibodies PAA231Mu01 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
PAA231Mu02 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
PAA231Mu08 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
Assay Kits CEA231Mu ELISA Kit for Urocortin (UCN) Enzyme-linked immunosorbent assay for Antigen Detection.
SEA231Mu ELISA Kit for Urocortin (UCN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA231Ra01 Recombinant Urocortin (UCN) Positive Control; Immunogen; SDS-PAGE; WB.
CPA231Ra21 OVA Conjugated Urocortin (UCN) Immunogen; SDS-PAGE; WB.
Antibodies PAA231Ra01 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
LAA231Ra71 Biotin-Linked Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC.
MAA231Ra21 Monoclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
PAA231Ra08 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
Assay Kits SEA231Ra ELISA Kit for Urocortin (UCN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA231Cp01 Recombinant Urocortin (UCN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA231Cp01 Polyclonal Antibody to Urocortin (UCN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Urocortin (UCN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Urocortin (UCN) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of human urocortin."Endocrinology 137:2167-2170(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The structures of the mouse and human urocortin genes (Ucn and UCN)."Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The skin produces urocortin."J. Clin. Endocrinol. Metab. 85:815-823(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Urocortin 1 in colonic mucosa in patients with ulcerative colitis."J. Clin. Endocrinol. Metab. 89:5352-5361(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]