Cathepsin K (CTSK)
[Edit]CTS-K; CTS02; CTSO; CTSO1; CTSO2; PKND; PYCD; Pycnodysostosis; Cathepsin O; Cathepsin X
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Cathepsin K is a lysosomal cysteine protease involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption.
The enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment of osteoporosis. Cathepsin K expression is stimulated by inflammatory cytokines that are released after tissue injury.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Hu01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA267Hu02 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA267Hu01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; ICC; IHC-P; IHC-F; ELISA. |
| MAA267Hu22 | Monoclonal Antibody to Cathepsin K (CTSK) | WB | |
| MAA267Hu21 | Monoclonal Antibody to Cathepsin K (CTSK) | WB | |
| PAA267Hu02 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. | |
| LAA267Hu72 | Biotin-Linked Monoclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC. | |
| Assay Kits | SEA267Hu | ELISA Kit for Cathepsin K (CTSK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Mu01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA267Mu02 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA267Mu01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| PAA267Mu02 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA267Mu | ELISA Kit for Cathepsin K (CTSK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Ra01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Ra01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| MAA267Ra21 | Monoclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA267Ra | ELISA Kit for Cathepsin K (CTSK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Rb01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Rb51 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cathepsin K (CTSK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cathepsin K (CTSK) | ELISA Kit Customized Service Offer |
Organism species: Rhesus monkey (Simian)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Si01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Si01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| LAA267Si71 | Biotin-Linked Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC. | |
| LAA267Si81 | FITC-Linked Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IF. | |
| MAA267Si21 | Monoclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Cathepsin K (CTSK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cathepsin K (CTSK) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Ca01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Ca01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cathepsin K (CTSK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cathepsin K (CTSK) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Po01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Po01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| LAA267Po81 | FITC-Linked Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IF. | |
| LAA267Po71 | Biotin-Linked Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC. | |
| MAA267Po21 | Monoclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA267Po | ELISA Kit for Cathepsin K (CTSK) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Bo01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Bo01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cathepsin K (CTSK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cathepsin K (CTSK) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA267Ga01 | Recombinant Cathepsin K (CTSK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA267Ga01 | Polyclonal Antibody to Cathepsin K (CTSK) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Cathepsin K (CTSK) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cathepsin K (CTSK) | ELISA Kit Customized Service Offer |
- "Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2."FEBS Lett. 357:129-134(1995) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone."Biochem. Biophys. Res. Commun. 206:89-96(1995) [PubMed] [Europe PMC] [Abstract]
- "Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas."J. Bone Miner. Res. 10:1197-1202(1995) [PubMed] [Europe PMC] [Abstract]
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- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human cathepsin K complexed with a potent inhibitor."Nat. Struct. Biol. 4:105-109(1997) [PubMed] [Europe PMC] [Abstract]
- "Design of potent and selective human cathepsin K inhibitors that span the active site." Proc. Natl. Acad. Sci. U.S.A. 94:14249-14254(1997) [PubMed] [Europe PMC] [Abstract]
- "The crystal structure of human procathepsin K."Biochemistry 38:862-869(1999) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of wild-type human procathepsin K."Protein Sci. 8:283-290(1999) [PubMed] [Europe PMC] [Abstract]
- "Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency."Science 273:1236-1238(1996) [PubMed] [Europe PMC] [Abstract]
- "Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis."Am. J. Hum. Genet. 62:848-854(1998) [PubMed] [Europe PMC] [Abstract]
- "Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein."J. Bone Miner. Res. 14:1649-1653(1999) [PubMed] [Europe PMC] [Abstract]
- "Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population."Eur. J. Hum. Genet. 8:431-436(2000) [PubMed] [Europe PMC] [Abstract]