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Transforming Growth Factor Beta Receptor I (TGFbR1)

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ACVRLK4; AAT5; ALK5; SKR4; TGFR-1; Activin A Receptor Type II-Like Kinase 53kDa; Activin receptor-like kinase 5; Serine/threonine-protein kinase receptor R4

Transforming Growth Factor Beta Receptor I (TGFbR1)
CCC A397
HGNC 11772
MGI 98728
PubMed 20813212
RGD 3852
UniProt P36897
Wiki TGFBR1

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome(LDAS).TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1. Both are transmembrane serine/threonine receptor kinases. The TGFBR1 receptor may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest. Vellucci and Reiss (1997) reported that the TGFBR1 gene is approximately 31 kb long and contains 9 exons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA397Hu01 Recombinant Transforming Growth Factor Beta Receptor I (TGFbR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA397Hu01 Polyclonal Antibody to Transforming Growth Factor Beta Receptor I (TGFbR1) WB; IHC; ICC; IP.
MAA397Hu22 Monoclonal Antibody to Transforming Growth Factor Beta Receptor I (TGFbR1) WB; IHC; ICC; IP.
Assay Kits SEA397Hu ELISA Kit for Transforming Growth Factor Beta Receptor I (TGFbR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA397Mu01 Recombinant Transforming Growth Factor Beta Receptor I (TGFbR1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA397Mu02 Recombinant Transforming Growth Factor Beta Receptor I (TGFbR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA397Mu01 Polyclonal Antibody to Transforming Growth Factor Beta Receptor I (TGFbR1) WB; IHC; ICC; IP.
PAA397Mu02 Polyclonal Antibody to Transforming Growth Factor Beta Receptor I (TGFbR1) WB; IHC; ICC; IP.
Assay Kits SEA397Mu ELISA Kit for Transforming Growth Factor Beta Receptor I (TGFbR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transforming Growth Factor Beta Receptor I (TGFbR1) Recombinant Protein Customized Service Offer
Antibodies PAA397Ra01 Polyclonal Antibody to Transforming Growth Factor Beta Receptor I (TGFbR1) WB; IHC; ICC; IP.
Assay Kits SEA397Ra ELISA Kit for Transforming Growth Factor Beta Receptor I (TGFbR1) Enzyme-linked immunosorbent assay for Antigen Detection.
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