Granzyme M (GZMM)
[Edit]GZM-M; LMET1; MET1; Hu-Met-1; Met-ase; Lymphocyte Met Ase 1; Met-1 serine protease; Natural killer cell granular protease
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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.
By fluorescence in situ hybridization, Pilat et al. (1994) mapped the GZMM gene to chromosome 19p13.3. Interphase studies with 2 differentially labeled probes for GZMM and the azurocidin (AZU1), proteinase-3 (PRTN3), and elastase-2 (ELA2) gene cluster indicated that the GZMM gene is 200 to 500 kb from that gene cluster.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA431Hu01 | Recombinant Granzyme M (GZMM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA431Hu01 | Active Granzyme M (GZMM) | Cell culture; Activity Assays. | |
| Antibodies | PAA431Hu01 | Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC |
| MAA431Hu22 | Monoclonal Antibody to Granzyme M (GZMM) | WB,IHC | |
| LAA431Hu71 | Biotin-Linked Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC. | |
| LAA431Hu81 | FITC-Linked Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC; IF. | |
| MAA431Hu23 | Monoclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA431Hu | ELISA Kit for Granzyme M (GZMM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA431Mu01 | Recombinant Granzyme M (GZMM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA431Mu02 | Recombinant Granzyme M (GZMM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA431Mu01 | Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC; IP. |
| PAA431Mu02 | Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA431Mu | ELISA Kit for Granzyme M (GZMM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA431Ra01 | Recombinant Granzyme M (GZMM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA431Ra01 | Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Granzyme M (GZMM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Granzyme M (GZMM) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA431Po01 | Recombinant Granzyme M (GZMM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA431Po01 | Polyclonal Antibody to Granzyme M (GZMM) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Granzyme M (GZMM) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Granzyme M (GZMM) | ELISA Kit Customized Service Offer |
- "Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells."J. Immunol. 151:6195-6205(1993) [PubMed] [Europe PMC] [Abstract]
- "The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3."Genomics 24:445-450(1994) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network."J. Immunol. 180:8184-8191(2008) [PubMed] [Europe PMC] [Abstract]
- "Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells."J. Biol. Chem. 285:18326-18335(2010) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M."J. Immunol. 183:421-429(2009) [PubMed] [Europe PMC] [Abstract]