≡

Caspase 14 (CASP14)

[Edit]

Caspase 14 Apoptosis-Related Cysteine Peptidase; Cysteinyl Aspartate Specific Proteinases 14

Caspase 14 (CASP14)
CCC A457
HGNC 1502
MGI 1335092
PubMed 12445205
RGD 1311781
UniProt P31944
Wiki Caspase_14
Caspase-14 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.
Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA457Hu01 Recombinant Caspase 14 (CASP14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA457Hu01 Polyclonal Antibody to Caspase 14 (CASP14) WB; IHC; ICC; IP.
MAA457Hu22 Monoclonal Antibody to Caspase 14 (CASP14) WB; IHC; ICC; IP.
Assay Kits SEA457Hu ELISA Kit for Caspase 14 (CASP14) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA457Hu CLIA Kit for Caspase 14 (CASP14) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA457Mu01 Recombinant Caspase 14 (CASP14) Positive Control; Immunogen; SDS-PAGE; WB.
RPA457Mu02 Recombinant Caspase 14 (CASP14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA457Mu01 Polyclonal Antibody to Caspase 14 (CASP14) WB; IHC; ICC; IP.
PAA457Mu02 Polyclonal Antibody to Caspase 14 (CASP14) WB; IHC; ICC; IP.
Assay Kits SEA457Mu ELISA Kit for Caspase 14 (CASP14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA457Ra01 Recombinant Caspase 14 (CASP14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA457Ra01 Polyclonal Antibody to Caspase 14 (CASP14) WB; IHC; ICC; IP.
MAA457Ra21 Monoclonal Antibody to Caspase 14 (CASP14) WB; IHC; ICC; IP.
Assay Kits SEA457Ra ELISA Kit for Caspase 14 (CASP14) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation."Biochem. Biophys. Res. Commun. 277:655-659(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Expression and transcriptional regulation of caspase-14 in simple and complex epithelia."Cell Death Differ. 9:995-1006(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing."Cell Death Differ. 7:1218-1224(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation."Biochem. Biophys. Res. Commun. 296:911-917(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Activation and substrate specificity of caspase-14."Biochemistry 43:10560-10569(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Stratum corneum-derived caspase-14 is catalytically active."FEBS Lett. 577:446-450(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression and characterization of constitutively active human caspase-14."Biochem. Biophys. Res. Commun. 347:941-948(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody."J. Cell. Biochem. 109:487-497(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form."J. Biol. Chem. 287:32825-32834(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema."Biomed. Res. Int. 2014:417986-417986(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation."Cell Death Dis. 5:E1181-E1181(2014) [PubMed] [Europe PMC] [Abstract]