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Vitamin D Receptor (VDR)

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NR1I1; Nuclear Receptor Subfamily 1 Group I Member 1; Calcitriol Receptor; 1,25-dihydroxyvitamin D3 receptor

Vitamin D Receptor (VDR)
CCC A475
HGNC 12679
MGI 103076
PubMed 18844852
RGD 3959
UniProt P11473
Wiki VDR

VDR is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA475Hu01 Recombinant Vitamin D Receptor (VDR) Positive Control; Immunogen; SDS-PAGE; WB.
APA475Hu01 Active Vitamin D Receptor (VDR) Cell culture; Activity Assays.
Antibodies PAA475Hu01 Polyclonal Antibody to Vitamin D Receptor (VDR) WB
MAA475Hu22 Monoclonal Antibody to Vitamin D Receptor (VDR) WB; IHC; ICC; IP.
Assay Kits SEA475Hu ELISA Kit for Vitamin D Receptor (VDR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA475Mu01 Recombinant Vitamin D Receptor (VDR) Positive Control; Immunogen; SDS-PAGE; WB.
RPA475Mu02 Recombinant Vitamin D Receptor (VDR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA475Mu01 Polyclonal Antibody to Vitamin D Receptor (VDR) WB; IHC; ICC; IP.
PAA475Mu02 Polyclonal Antibody to Vitamin D Receptor (VDR) WB; IHC; ICC; IP.
Assay Kits SEA475Mu ELISA Kit for Vitamin D Receptor (VDR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA475Ra01 Recombinant Vitamin D Receptor (VDR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA475Ra01 Polyclonal Antibody to Vitamin D Receptor (VDR) WB; IHC; ICC; IP.
MAA475Ra21 Monoclonal Antibody to Vitamin D Receptor (VDR) WB; IHC; ICC; IP.
Assay Kits SEA475Ra ELISA Kit for Vitamin D Receptor (VDR) Enzyme-linked immunosorbent assay for Antigen Detection.
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  9. "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."Cell 90:569-580(1997) [PubMed] [Europe PMC] [Abstract]
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  20. "Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues."J. Med. Chem. 49:5199-5205(2006) [PubMed] [Europe PMC] [Abstract]
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  23. "A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection."Am. J. Hum. Genet. 49:668-673(1991) [PubMed] [Europe PMC] [Abstract]
  24. "A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1,25-dihydroxyvitamin D3."Mol. Endocrinol. 4:623-631(1990) [PubMed] [Europe PMC] [Abstract]
  25. "Hereditary 1 alpha,25-dihydroxyvitamin D-resistant rickets resulting from a mutation in the vitamin D receptor deoxyribonucleic acid-binding domain."J. Clin. Endocrinol. Metab. 78:313-316(1994) [PubMed] [Europe PMC] [Abstract]
  26. "Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3."J. Clin. Invest. 92:12-16(1993) [PubMed] [Europe PMC] [Abstract]
  27. "Two mutations causing vitamin D resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures."Clin. Endocrinol. (Oxf.) 41:581-590(1994) [PubMed] [Europe PMC] [Abstract]
  28. "A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets."J. Clin. Endocrinol. Metab. 81:2564-2569(1996) [PubMed] [Europe PMC] [Abstract]
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