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Cytokeratin 4 (CK4)

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CYK4; KRT4; K4; Keratin 4; Keratin, type II cytoskeletal 4; Type-II keratin Kb4

Cytokeratin 4 (CK4)
CCC A489
HGNC 6441
MGI 96701
PubMed 10692107
RGD 1359272
UniProt P19013
Wiki Cytokeratin_4

Keratin 4 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13.

Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq]. Sequence Note: The RefSeq represents one of two co-dominant alleles identified for this gene.
 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA489Hu01 Recombinant Cytokeratin 4 (CK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA489Hu01 Polyclonal Antibody to Cytokeratin 4 (CK4) WB; IHC; ICC; IP.
MAA489Hu22 Monoclonal Antibody to Cytokeratin 4 (CK4) WB; IHC; ICC; IP.
Assay Kits SEA489Hu ELISA Kit for Cytokeratin 4 (CK4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA489Mu01 Recombinant Cytokeratin 4 (CK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA489Mu01 Polyclonal Antibody to Cytokeratin 4 (CK4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytokeratin 4 (CK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 4 (CK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA489Ra01 Recombinant Cytokeratin 4 (CK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA489Ra01 Polyclonal Antibody to Cytokeratin 4 (CK4) WB; IHC; ICC; IP.
LAA489Ra71 Biotin-Linked Polyclonal Antibody to Cytokeratin 4 (CK4) WB; IHC; ICC.
MAA489Ra21 Monoclonal Antibody to Cytokeratin 4 (CK4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytokeratin 4 (CK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 4 (CK4) ELISA Kit Customized Service Offer
  1. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Allelic variations of human keratins K4 and K5 provide polymorphic markers within the type II keratin gene cluster on chromosome 12."J. Invest. Dermatol. 100:735-741(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15."J. Cell Biol. 106:1249-1261(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene in a familial case of white sponge nevus."J. Invest. Dermatol. 114:388-391(2000) [PubMed] [Europe PMC] [Abstract]
  7. "A novel mutation in the keratin 4 gene causing white sponge naevus."Br. J. Dermatol. 148:1125-1128(2003) [PubMed] [Europe PMC] [Abstract]