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Cytokeratin 16 (CK16)

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KRT16; NEPPK; Keratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin, type I cytoskeletal 16

Cytokeratin 16 (CK16)
CCC A516
HGNC 6423
MGI 96690
PubMed 12445204
RGD 1590901
UniProt P08779
Wiki Keratin_16

Keratin 16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21.

This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA516Hu01 Recombinant Cytokeratin 16 (CK16) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA516Hu01 Polyclonal Antibody to Cytokeratin 16 (CK16) WB; IHC; ICC; IP.
MAA516Hu22 Monoclonal Antibody to Cytokeratin 16 (CK16) WB; IHC; ICC; IP.
LAA516Hu71 Biotin-Linked Polyclonal Antibody to Cytokeratin 16 (CK16) WB; IHC; ICC.
LAA516Hu81 FITC-Linked Polyclonal Antibody to Cytokeratin 16 (CK16) WB; IHC; ICC; IF.
Assay Kits SEA516Hu ELISA Kit for Cytokeratin 16 (CK16) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytokeratin 16 (CK16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytokeratin 16 (CK16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytokeratin 16 (CK16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytokeratin 16 (CK16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 16 (CK16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytokeratin 16 (CK16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytokeratin 16 (CK16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytokeratin 16 (CK16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytokeratin 16 (CK16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 16 (CK16) ELISA Kit Customized Service Offer
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  2. "A group of type I keratin genes on human chromosome 17: characterization and expression."Mol. Cell. Biol. 8:722-736(1988) [PubMed] [Europe PMC] [Abstract]
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  7. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
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  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Novel mutations in keratin 16 gene underly focal nonepidermolytic palmoplantar keratoderma (NEPPK) in two families."Hum. Mol. Genet. 4:1875-1881(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1."Br. J. Dermatol. 141:1010-1016(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Cloning of multiple keratin 16 genes facilitates prenatal diagnosis of pachyonychia congenita type 1."Prenat. Diagn. 19:941-946(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma."Exp. Dermatol. 9:170-177(2000) [PubMed] [Europe PMC] [Abstract]
  16. "A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus."J. Invest. Dermatol. 114:1136-1140(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16."Br. J. Dermatol. 144:1058-1062(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita."J. Invest. Dermatol. 117:1391-1396(2001) [PubMed] [Europe PMC] [Abstract]
  19. "The genetic basis of pachyonychia congenita."J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]
  20. "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]
  21. "A large mutational study in pachyonychia congenita."J. Invest. Dermatol. 131:1018-1024(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Genotype-phenotype correlations among pachyonychia congenita patients with K16 mutations."J. Invest. Dermatol. 131:1025-1028(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma."Eur. J. Dermatol. 22:476-480(2012) [PubMed] [Europe PMC] [Abstract]
  24. "A new KRT16 mutation associated with a phenotype of pachyonychia congenita."Exp. Dermatol. 22:838-839(2013) [PubMed] [Europe PMC] [Abstract]