P-Selectin (SELP)

[Edit]

CD62P; Selectin, Platelet; PSEL; GMP140; LECAM3; GRMP; GMRP; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; Platelet activation dependent granule-external membrane

P-Selectin (SELP)

P-selectin is the largest of the known selectins at 140kDa. It contains nine consensus repeats (CR) and extends approximately 40 nm from the endothelial surface. P-selectin is expressed in a-granules of activated platelets and granules of endothelial cells. Within minutes of stimulation of the endothelial cells by inflammatory mediators such as histamine, thrombin, or phorbol esters, P-selectin is surface-expressed. Expression of P-selectin also occurs from the surgical trauma endured during preparation of the tissues for intravital microscopy. The expression is short-lived, reaching its peak after only ten minutes. Additional synthesis of P-selectin is brought about within two hours by cytokines such as interleukin-1 (IL-1) or tumor necrosis factor a (TNF-a).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA569Hu01 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA569Hu02 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
EPA569Hu61 Eukaryotic P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
APA569Hu61 Active P-Selectin (SELP) Cell culture; Activity Assays.
RPA569Hu03 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA569Hu01 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
MAA569Hu22 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
LAA569Hu71 Biotin-Linked Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC.
LAA569Hu81 FITC-Linked Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IF.
MAA569Hu21 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
PAA569Hu02 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
MAA569Hu23 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
MAA569Hu24 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
Assay Kits SEA569Hu ELISA Kit for P-Selectin (SELP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA569Hu CLIA Kit for P-Selectin (SELP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA569Mu01 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA569Mu02 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA569Mu01 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
LAA569Mu71 Biotin-Linked Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC.
LAA569Mu81 FITC-Linked Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IF.
PAA569Mu02 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
Assay Kits SEA569Mu ELISA Kit for P-Selectin (SELP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA569Mu CLIA Kit for P-Selectin (SELP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA569Ra01 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA569Ra01 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
LAA569Ra71 Biotin-Linked Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC.
MAA569Ra21 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
Assay Kits SEA569Ra ELISA Kit for P-Selectin (SELP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA569Rb01 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA569Rb51 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
MAA569Rb21 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
PAA569Rb01 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
Assay Kits SEA569Rb ELISA Kit for P-Selectin (SELP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA569Po01 Recombinant P-Selectin (SELP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA569Po01 Polyclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
MAA569Po21 Monoclonal Antibody to P-Selectin (SELP) WB; IHC; ICC; IP.
Assay Kits SEA569Po ELISA Kit for P-Selectin (SELP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation."Cell 56:1033-1044(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage."J. Biol. Chem. 268:11394-11400(1993) [PubMed] [Europe PMC] [Abstract]
  4. "A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding."Cell 83:323-331(1995) [PubMed] [Europe PMC] [Abstract]
  5. "PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus."Cell 83:333-343(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin."J. Biol. Chem. 270:22677-22680(1995) [PubMed] [Europe PMC] [Abstract]
  7. "A new member of the sorting nexin family interacts with the C-terminus of P-selectin."Biochem. Biophys. Res. Commun. 281:1045-1050(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking."J. Mol. Biol. 347:813-825(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Structure and function of the epidermal growth factor domain of P-selectin."Biochemistry 35:13733-13744(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Knowledge-based model building of proteins: concepts and examples."Protein Sci. 2:1798-1810(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]
  14. ErratumCell 105:971-971(2001)
  15. "The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction."Hum. Mol. Genet. 7:1277-1284(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  17. ErratumNat. Genet. 23:373-373(1999)
  18. "Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis."Hum. Mol. Genet. 13:389-396(2004) [PubMed] [Europe PMC] [Abstract]