Pyruvate kinase isozymes M2 (PKM2)
[Edit]M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein; Pyruvate Kinase, Muscle
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Pyruvate Kinase M2 (M2-PK) is strongly overexpressed in a metabolic state specific for a variety of tumor cells. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and. lung cancer. It has also been investigated in. pancreatic cancer and gastric cancer with promising results.
M2-PK is encoded by the gene PKM2 which does also encode for the pyruvate kinase isoenzyme type M1 (PKM1 or M1-PK). The M-gene consists of 12 exons and 11 introns. PKM1 and PKM2 are different splicing products of the M-gene (exon 9 for PKM1 and exon 10 for PKM2) and solely differ in 23 amino acids within a 56 amino acid stretch (aa 378-434) at their carboxy terminus.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA588Mu01 | Recombinant Pyruvate kinase isozymes M2 (PKM2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA588Mu02 | Recombinant Pyruvate kinase isozymes M2 (PKM2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA588Mu03 | Recombinant Pyruvate kinase isozymes M2 (PKM2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA588Mu01 | Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) | WB; IHC; ICC; IP. |
| PAA588Mu02 | Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA588Mu | ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA588Ra01 | Recombinant Pyruvate kinase isozymes M2 (PKM2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA588Ra01 | Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) | WB; IHC; ICC; IP. |
| MAA588Ra21 | Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA588Ra | ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Hamster (Chinese hamster)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | CPA588Ha21 | OVA Conjugated Pyruvate kinase isozymes M2 (PKM2) | Immunogen; SDS-PAGE; WB. |
| RPA588Ha01 | Recombinant Pyruvate kinase isozymes M2 (PKM2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA588Ha08 | Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) | WB |
| Assay Kits | n/a | CLIA Kit for Pyruvate kinase isozymes M2 (PKM2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) | ELISA Kit Customized Service Offer |
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- ErratumProc. Natl. Acad. Sci. U.S.A. 87:1625-1625(1990)
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