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Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2)

M2PK; PKM; M2-PK; PKM1; CTHBP; OIP3; PK3; PKM; TCB; THBP1; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; Cytosolic thyroid hormone-binding protein; Pyruvate Kinase, Muscle

  • Product No.MAA588Hu24
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceMonoclonal antibody preparation
  • HostMouse
  • Potency (Clone Number)D7
  • Ig Isotype IgG
  • PurificationAntigen-specific affinity chromatography followed by Protein A affinity chromatography
  • LabelNone
  • Immunogen n/a
  • Buffer FormulationPBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
  • TraitsLiquid
  • Concentration1mg/mL
  • Organism Species Moren/a
  • ApplicationsWB; IHC; ICC; IP.
    If the antibody is used in flow cytometry, please check FCM antibodies.
  • Downloadn/a
  • UOM 20µl100µl 200µl 1ml 10ml
  • FOB US$ 102  US$ 239  US$ 341  US$ 853  US$ 3410 
    For more details, please contact local distributors!

SPECIFITY

The antibody is a mouse monoclonal antibody raised against PKM2. It has been selected for its ability to recognize PKM2 in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.2-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Cancer Research Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3 AACR: 70189
Molecular BioSystems Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer Pubmed:25483567
Tumour Biol M2 isoform of pyruvate kinase (PKM2) is upregulated in Kazakh’s ESCC and promotes proliferation and migration of ESCC cells PubMed: 26404132
Oncotarget Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholangitis Pubmed:29707118
Journal of Neurotrauma Acteoside improves muscle atrophy and motor function by inducing new myokine secretion in chronic spinal cord injury Pubmed: 30318996
Cell Reports Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway Pubmed: 32049010
Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)
Cancer Cell International Bufalin Induced Mitochondrial Dysfunction Promotes Apoptosis of Glioma Cells by Regulating Annexin A2 and DRP1 Proteins
Cancer Cell Int Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression 34376212
Life (Basel) Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib 34947916
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
RPA588Hu01 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Hu02 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA588Hu03 Recombinant Pyruvate kinase isozymes M2 (PKM2) Positive Control; Immunogen; SDS-PAGE; WB.
APA588Hu02 Active Pyruvate kinase isozymes M2 (PKM2) Cell culture; Activity Assays.
PAA588Hu02 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; IF;FCM
PAA588Hu03 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
PAA588Hu01 Polyclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB,IHC,ICC/IF; FCM
FAA588Hu01 Anti-Pyruvate kinase isozymes M2 (PKM2) Polyclonal Antibody Flow cytometry.
FAA588Hu03 Anti-Pyruvate kinase isozymes M2 (PKM2) Polyclonal Antibody Flow cytometry.
MAA588Hu24 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Hu22 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Hu23 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
MAA588Hu21 Monoclonal Antibody to Pyruvate kinase isozymes M2 (PKM2) WB; IHC; ICC; IP.
SEA588Hu ELISA Kit for Pyruvate kinase isozymes M2 (PKM2) Enzyme-linked immunosorbent assay for Antigen Detection.
LMA588Hu Multiplex Assay Kit for Pyruvate kinase isozymes M2 (PKM2) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.