Mucin 2 (MUC2)

[Edit]

MLP; SMUC; Oligomeric Mucus/Gel-Forming; Mucin 2,Intestinal/Tracheal

Mucin 2 (MUC2)

Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is oligosaccharide side chains which are added as post-translational modifications to the mucin proteins. This gel provides an insoluble mucous barrier that serves to protect the intestinal epithelium.

The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA705Hu01 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA705Hu01 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
MAA705Hu22 Monoclonal Antibody to Mucin 2 (MUC2) WB
LAA705Hu71 Biotin-Linked Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC.
MAA705Hu21 Monoclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
MAA705Hu24 Monoclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
Assay Kits SEA705Hu ELISA Kit for Mucin 2 (MUC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA705Mu01 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA705Mu02 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA705Mu03 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA705Mu01 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC
PAA705Mu02 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
PAA705Mu03 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
LAA705Mu71 Biotin-Linked Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC.
LAA705Mu81 FITC-Linked Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IF.
Assay Kits SEA705Mu ELISA Kit for Mucin 2 (MUC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA705Ra01 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA705Ra02 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA705Ra01 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
MAA705Ra21 Monoclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
Assay Kits SEA705Ra ELISA Kit for Mucin 2 (MUC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA705Po01 Recombinant Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
NPA705Po01 Native Mucin 2 (MUC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA705Po05 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC; ICC; IP.
PAA705Po01 Polyclonal Antibody to Mucin 2 (MUC2) WB; IHC
Assay Kits n/a CLIA Kit for Mucin 2 (MUC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mucin 2 (MUC2) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor."J. Biol. Chem. 269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region."J. Biol. Chem. 267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract]
  3. "MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism."J. Clin. Invest. 88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism."J. Biol. Chem. 264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5."Biochem. Biophys. Res. Commun. 183:821-828(1992) [PubMed] [Europe PMC] [Abstract]
  6. "In vivo glycosylation of mucin tandem repeats."Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment."J. Biol. Chem. 277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract]
  8. "An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway."J. Biol. Chem. 278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]