Osteopontin (OPN)

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SPP1; BNSP; BSPI; ETA1; Secreted Phosphoprotein 1; Bone Sialoprotein I; Early T-Lymphocyte Activation 1; Nephropontin; Urinary stone protein; Uropontin

Osteopontin (OPN)

Osteopontin (OPN), is a secreted multifunctional glyco-phosphoprotein with roles in bone metabolism, immune regulation, tissue remodeling , cell survival, and tumor progression . Gene structure and chromosomal location identify OPN as a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that also includes BSP,BMP1,DSPP, ENAM and MEPE. Murine OPN issynthesized as a 294 amino acid (aa) precursor protein with a predicted 16 aa signal peptide and a highly unusual mature protein sequence, containing 68 acidic aa and 23 potential Ser/Thr phosphorylation sites. Although the predicted molecular weight of OPN is 31 kDa,phosphorylation and N- and O-glycosylation may allow it to appear as large as 75 kDa. Variability in post-translational modifications can influence the activity of OPN.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Hu02 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA899Hu61 Eukaryotic Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
APA899Hu61 Active Osteopontin (OPN) Cell culture; Activity Assays.
EPA899Hu62 Eukaryotic Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA899Hu22 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
LAA899Hu71 Biotin-Linked Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC.
PAA899Hu02 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP; FCM
PAA899Hu06 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Hu21 Monoclonal Antibody to Osteopontin (OPN) WB
MAA899Hu23 Monoclonal Antibody to Osteopontin (OPN) WB
MAA899Hu24 Monoclonal Antibody to Osteopontin (OPN) WB
MAA899Hu25 Monoclonal Antibody to Osteopontin (OPN) WB
Assay Kits SEA899Hu ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA899Hu CLIA Kit for Osteopontin (OPN) Chemiluminescent immunoassay for Antigen Detection.
AEA899Hu ELISA Kit for Anti-Osteopontin Antibody (Anti-OPN) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Mu01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA899Mu02 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA899Mu61 Eukaryotic Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
APA899Mu61 Active Osteopontin (OPN) Cell culture; Activity Assays.
RPA899Mu03 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA899Mu01 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
PAA899Mu02 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
PAA899Mu06 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
Assay Kits SEA899Mu ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA899Mu CLIA Kit for Osteopontin (OPN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Ra01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA899Ra61 Eukaryotic Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
APA899Ra61 Active Osteopontin (OPN) Cell culture; Activity Assays.
Antibodies PAA899Ra01 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Ra21 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
PAA899Ra06 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
Assay Kits SEA899Ra ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Rb01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA899Rb51 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Rb21 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
Assay Kits SEA899Rb ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Si01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA899Si01 Polyclonal Antibody to Osteopontin (OPN) WB,IHC
Assay Kits SEA899Si ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Ca01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
RPA899Ca02 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA899Ca01 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
LAA899Ca71 Biotin-Linked Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC.
Assay Kits SEA899Ca ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.
HEA899Ca High Sensitive ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Po01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA899Po01 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Po21 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Po22 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Po23 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Po24 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
Assay Kits SEA899Po ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA899Bo01 Recombinant Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
EPA899Bo61 Eukaryotic Osteopontin (OPN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA899Bo01 Polyclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
MAA899Bo21 Monoclonal Antibody to Osteopontin (OPN) WB; IHC; ICC; IP.
Assay Kits SEA899Bo ELISA Kit for Osteopontin (OPN) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)."Genomics 7:491-502(1990) [PubMed] [Europe PMC] [Abstract]
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  12. "Purification of a human milk protein closely similar to tumor-secreted phosphoproteins and osteopontin."Biochim. Biophys. Acta 996:43-48(1989) [PubMed] [Europe PMC] [Abstract]
  13. "Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications."Biochem. J. 390:285-292(2005) [PubMed] [Europe PMC] [Abstract]
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  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
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