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Glypican 3 (GPC3)

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DGSX; OCI5; SDYS; SGB; SGBS1; MXR7; Glypican Proteoglycan 3; GTR2-2; Intestinal protein OCI-5; Secreted glypican-3

Glypican 3 (GPC3)
CCC A971
HGNC 4451
MGI 104903
PubMed 11008203
RGD 2725
UniProt P51654
Wiki GPC3

Glypican 3, also known as GPC3, The protein encoded by this gene is a member of the glypican family.Glypican 3 immunostaining has utility for differentiating hepatocellular carcinoma (HCC) and dysplastic changes in cirrhotic livers; HCC stains with glypican 3, while liver with dysplastic changes and/or cirrhotic changes does not.

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA971Hu01 Recombinant Glypican 3 (GPC3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA971Hu02 Recombinant Glypican 3 (GPC3) Positive Control; Immunogen; SDS-PAGE; WB.
APA971Hu01 Active Glypican 3 (GPC3) Cell culture; Activity Assays.
APA971Hu02 Active Glypican 3 (GPC3) Cell culture; Activity Assays.
Antibodies PAA971Hu01 Polyclonal Antibody to Glypican 3 (GPC3) WB; ICC; IHC-P; IHC-F; ELISA.
MAA971Hu22 Monoclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
MAA971Hu21 Monoclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
MAA971Hu24 Monoclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
MAA971Hu23 Monoclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
MAA971Hu25 Monoclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
Assay Kits SEA971Hu ELISA Kit for Glypican 3 (GPC3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA971Mu01 Recombinant Glypican 3 (GPC3) Positive Control; Immunogen; SDS-PAGE; WB.
APA971Mu01 Active Glypican 3 (GPC3) Cell culture; Activity Assays.
Antibodies PAA971Mu01 Polyclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
Assay Kits SEA971Mu ELISA Kit for Glypican 3 (GPC3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA971Ra01 Recombinant Glypican 3 (GPC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA971Ra01 Polyclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
MAA971Ra21 Monoclonal Antibody to Glypican 3 (GPC3) WB; IHC; ICC; IP.
Assay Kits SEA971Ra ELISA Kit for Glypican 3 (GPC3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization."Mamm. Genome 8:72-72(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome."Nat. Genet. 12:241-247(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5."Gene 188:151-156(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene."Genomics 45:48-58(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26."Proteomics 7:2300-2310(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."Hum. Mol. Genet. 9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]