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Alpha-2-Macroglobulin (a2M)

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A2MG; A2mg; CPAMD5; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

Alpha-2-Macroglobulin (a2M)
CCC B017
HGNC 7
MGI 2449119
PubMed 23086799
RGD 2004
UniProt P01023
Wiki A2M

Alpha2-macroglobulin is a major serum protein with diverse functions, including inhibition of protease activity and binding of growth factors, cytokines, and disease factors. It is also a panproteinase inhibitor that is found immunohistochemically in neuritic plaques.

Alpha-2-macroglobulin is able to inactivate an enormous variety of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). Alpha-2-macroglobulin has in its structure a 35 aminoacid "bait" region. Proteinases binding and cleaving the bait region become bound to alpha2M. The proteinase-α2M complex is recognised by macrophage receptors and cleared from the system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB017Hu01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB017Hu01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
MAB017Hu22 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
LAB017Hu71 Biotin-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC.
MAB017Hu21 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
MAB017Hu23 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
Assay Kits SEB017Hu ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB017Hu CLIA Kit for Alpha-2-Macroglobulin (a2M) Chemiluminescent immunoassay for Antigen Detection.
HEB017Hu High Sensitive ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB017Mu01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
RPB017Mu02 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
RPB017Mu03 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
RPB017Mu04 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB017Mu01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAB017Mu02 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAB017Mu03 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
LAB017Mu73 Biotin-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC.
LAB017Mu83 FITC-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IF.
Assay Kits CEB017Mu ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB017Ra01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
RPB017Ra02 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
RPB017Ra03 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB017Ra01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAB017Ra02 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAB017Ra03 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
LAB017Ra71 Biotin-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC.
MAB017Ra21 Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
Assay Kits SEB017Ra ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection.
CEB017Ra ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB017Rb01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB017Rb51 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
PAB017Rb01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-2-Macroglobulin (a2M) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alpha-2-Macroglobulin (a2M) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alpha-2-Macroglobulin (a2M) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) Polyclonal Antibody Customized Service Offer
Assay Kits SEB017Si ELISA Kit for Alpha-2-Macroglobulin (a2M) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB017Po01 Recombinant Alpha-2-Macroglobulin (a2M) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB017Po01 Polyclonal Antibody to Alpha-2-Macroglobulin (a2M) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-2-Macroglobulin (a2M) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-2-Macroglobulin (a2M) ELISA Kit Customized Service Offer
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  19. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  21. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin."Protein Sci. 7:2602-2612(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3."Biochem. J. 407:23-30(2007) [PubMed] [Europe PMC] [Abstract]
  26. "Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene."Nucleic Acids Res. 19:198-198(1991) [PubMed] [Europe PMC] [Abstract]