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Epithelial Cell Adhesion Molecule (EPCAM)

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CD326; TACSTD1; EGP; KSA; M4S1; MIC18; TROP1; HEGP2; ESA; Epithelial glycoprotein; Adenocarcinoma-associated antigen; Tumor Associated Calcium Signal Transducer 1

Epithelial Cell Adhesion Molecule (EPCAM)
CCC B283
HGNC 11529
MGI 106653
PubMed 21281469
RGD 621365
UniProt P16422
Wiki EpCAM
The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ~40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia express EpCAM at a variable but generally lower level than carcinoma cells. In early studies, EpCAM was proposed to be a cell-cell adhesion molecule.
However, recent insights revealed a more versatile role for EpCAM that is not limited only to cell adhesion but includes diverse processes such as signaling, cell migration, proliferation, and differentiation. Cell surface expression of EpCAM may actually prevent cell-cell adhesion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB283Hu01 Recombinant Epithelial Cell Adhesion Molecule (EPCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB283Hu01 Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) WB; IHC; ICC; IP.
MAB283Hu22 Monoclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) WB; IHC; ICC; IP.
MAB283Hu21 Monoclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) WB; IHC; ICC; IP.
Assay Kits SEB283Hu ELISA Kit for Epithelial Cell Adhesion Molecule (EPCAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epithelial Cell Adhesion Molecule (EPCAM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Epithelial Cell Adhesion Molecule (EPCAM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB283Po01 Recombinant Epithelial Cell Adhesion Molecule (EPCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB283Po01 Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) WB; IHC
Assay Kits n/a CLIA Kit for Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB283Ga01 Recombinant Epithelial Cell Adhesion Molecule (EPCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB283Ga01 Polyclonal Antibody to Epithelial Cell Adhesion Molecule (EPCAM) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit Customized Service Offer
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  2. "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker."J. Immunol. 142:3662-3667(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein."Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2."Proc. Natl. Acad. Sci. U.S.A. 87:3542-3546(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Retroposition in a family of carcinoma-associated antigen genes."Mol. Cell. Biol. 13:1507-1515(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
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  8. "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733."Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody."J. Biol. Chem. 268:24232-24241(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)."J. Biol. Chem. 276:5804-5813(2001) [PubMed] [Europe PMC] [Abstract]
  11. "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation."Oncogene 23:5748-5758(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP."Cancer Lett. 225:151-157(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."Exp. Cell Res. 309:345-357(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM."Front. Biosci. 13:5195-5201(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1."Nat. Genet. 41:112-117(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells."J. Biol. Chem. 285:8719-8732(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells."Stem Cells 28:29-35(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of EpCAM as the gene for congenital tufting enteropathy."Gastroenterology 135:429-437(2008) [PubMed] [Europe PMC] [Abstract]