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Integrin Beta 4 (ITGb4)

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CD104; ITG-B4; GP150

Integrin Beta 4 (ITGb4)
CCC B440
HGNC 6158
MGI 96613
PubMed 9792864
RGD 2928
UniProt P16144
Wiki ITGB4

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the ITGB4) subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma.

Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB440Hu01 Recombinant Integrin Beta 4 (ITGb4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB440Hu01 Polyclonal Antibody to Integrin Beta 4 (ITGb4) WB; IHC; ICC; IP.
MAB440Hu22 Monoclonal Antibody to Integrin Beta 4 (ITGb4) WB; IHC; ICC; IP.
PAB440Hu02 Polyclonal Antibody to Integrin Beta 4 (ITGb4) WB; IHC; ICC; IP; FCM
Assay Kits SEB440Hu ELISA Kit for Integrin Beta 4 (ITGb4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB440Mu01 Recombinant Integrin Beta 4 (ITGb4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB440Mu01 Polyclonal Antibody to Integrin Beta 4 (ITGb4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Integrin Beta 4 (ITGb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 4 (ITGb4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Beta 4 (ITGb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Beta 4 (ITGb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Beta 4 (ITGb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Beta 4 (ITGb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Beta 4 (ITGb4) ELISA Kit Customized Service Offer
  1. "Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells."EMBO J. 9:757-763(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain."EMBO J. 9:765-770(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4."J. Cell Biol. 111:1593-1604(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia."Lab. Invest. 76:823-833(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization of the human integrin beta 4 gene."Mamm. Genome 8:448-450(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences."Biochem. Biophys. Res. Commun. 235:826-830(1997) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors."EMBO J. 8:673-680(1989) [PubMed] [Europe PMC] [Abstract]
  10. "A novel structural variant of the human beta 4 integrin cDNA."Cell Adhes. Commun. 2:1-6(1994) [PubMed] [Europe PMC] [Abstract]
  11. "The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome."Mol. Biol. Cell 11:277-286(2000) [PubMed] [Europe PMC] [Abstract]
  12. "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression."J. Biol. Chem. 276:32427-32436(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly."J. Cell Sci. 116:387-399(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Palmitoylation supports assembly and function of integrin-tetraspanin complexes."J. Cell Biol. 167:1231-1240(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  16. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities."Mol. Biol. Cell 20:2954-2962(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4."Cell. Mol. Life Sci. 69:2233-2244(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4."EMBO J. 18:4087-4095(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of the fibronectin type III domain of human integrin beta-4."Submitted (APR-2008) to the PDB data bank
  24. "Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: missense versus nonsense."Am. J. Hum. Genet. 63:1376-1387(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Epidermolysis bullosa with pyloric atresia: novel mutations in the beta-4 integrin gene (ITGB4)."Am. J. Pathol. 152:157-166(1998) [PubMed] [Europe PMC] [Abstract]
  26. "Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta-4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia."Am. J. Pathol. 152:935-941(1998) [PubMed] [Europe PMC] [Abstract]
  27. "Pyloric atresia-junctional epidermolysis bullosa syndrome: mutations in the integrin beta4 gene (ITGB4) in two unrelated patients with mild disease."Br. J. Dermatol. 139:862-871(1998) [PubMed] [Europe PMC] [Abstract]
  28. "Congenital focal segmental glomerulosclerosis associated with beta4 integrin mutation and epidermolysis bullosa."Am. J. Kidney Dis. 36:190-196(2000) [PubMed] [Europe PMC] [Abstract]
  29. "A homozygous missense mutation in the cytoplasmic tail of beta4 integrin, G931D, that disrupts hemidesmosome assembly and underlies non-Herlitz junctional epidermolysis bullosa without pyloric atresia?"J. Invest. Dermatol. 114:1061-1064(2000) [PubMed] [Europe PMC] [Abstract]
  30. "Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia."Br. J. Dermatol. 144:408-414(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Nine novel single-nucleotide polymorphisms in the integrin beta4 (ITGB4) gene in the Japanese population."J. Hum. Genet. 46:35-37(2001) [PubMed] [Europe PMC] [Abstract]
  32. "Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations."Pediatr. Res. 49:618-626(2001) [PubMed] [Europe PMC] [Abstract]