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Interferon Regulatory Factor 8 (IRF8)

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H-ICSBP; ICS-BP; ICSBP1; Interferon Consensus Sequence-Binding Protein 1

Interferon Regulatory Factor 8 (IRF8)
CCC B776
HGNC 5358
MGI 96395
PubMed 21587231
RGD 1312024
UniProt Q02556
Wiki IRF8

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha; and IFN-beta;. IRF family proteins also control expression of IFN-alpha; and IFN-beta;-regulated genes that are induced by viral infection..
Mouse IFN-producing cells (mIPCs) were absent in all lymphoid organs from ICSBP KO mice, as revealed by lack of CD11c(low)B220(+)Ly6C(+)CD11b(-) cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB776Hu01 Recombinant Interferon Regulatory Factor 8 (IRF8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB776Hu01 Polyclonal Antibody to Interferon Regulatory Factor 8 (IRF8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 8 (IRF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 8 (IRF8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB776Mu01 Recombinant Interferon Regulatory Factor 8 (IRF8) Positive Control; Immunogen; SDS-PAGE; WB.
APB776Mu01 Active Interferon Regulatory Factor 8 (IRF8) Cell culture; Activity Assays.
Antibodies PAB776Mu01 Polyclonal Antibody to Interferon Regulatory Factor 8 (IRF8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 8 (IRF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 8 (IRF8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 8 (IRF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 8 (IRF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 8 (IRF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 8 (IRF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 8 (IRF8) ELISA Kit Customized Service Offer
  1. "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes."J. Biol. Chem. 267:25589-25596(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome."J. Biol. Chem. 275:39081-39089(2000) [PubMed] [Europe PMC] [Abstract]
  4. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
  5. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  6. "IRF8 mutations and human dendritic-cell immunodeficiency." N. Engl. J. Med. 365:127-138(2011) [PubMed] [Europe PMC] [Abstract]