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SMAD family member 5 (SMAD5)

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MADH5; Dwfc; JV5-1; Mothers Against Decapentaplegic Homolog 5

SMAD family member 5 (SMAD5)
CCC C122
HGNC 6771
MGI 1328787
PubMed 10207140
RGD 620158
UniProt Q99717
Wiki SMAD5

SMAD5 or Mothers against decapentaplegic homolog 5 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF beta superfamily of modulators. Like many other TGF beta family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's).

The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGF beta is an inhibitor of hematopoietic progenitor cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC122Hu01 Recombinant SMAD family member 5 (SMAD5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC122Hu01 Polyclonal Antibody to SMAD family member 5 (SMAD5) WB; IHC; ICC; IP.
Assay Kits SEC122Hu ELISA Kit for SMAD family member 5 (SMAD5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SMAD family member 5 (SMAD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SMAD family member 5 (SMAD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SMAD family member 5 (SMAD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SMAD family member 5 (SMAD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SMAD family member 5 (SMAD5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SMAD family member 5 (SMAD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SMAD family member 5 (SMAD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SMAD family member 5 (SMAD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SMAD family member 5 (SMAD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for SMAD family member 5 (SMAD5) ELISA Kit Customized Service Offer
  1. "Mad-related genes in the human."Nat. Genet. 13:347-349(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Localization of SMAD5 and its evaluation as a candidate myeloid tumor suppressor."Cancer Res. 57:3779-3783(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60."Leukemia 11:1187-1192(1997) [PubMed] [Europe PMC] [Abstract]
  4. "hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors."Oncogene 16:951-956(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12."J. Biol. Chem. 273:1872-1879(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]