≡

Histone Deacetylase 1 (HDAC1)

[Edit]

HDAC1; GON10; HD1; RPD3; RPD3L1

Histone Deacetylase 1 (HDAC1)
CCC C206
HGNC 4852
MGI 108086
PubMed 11960997
RGD 1309799
UniProt Q13547
Wiki HDAC1
Histone deacetylase 1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC206Hu01 Recombinant Histone Deacetylase 1 (HDAC1) Positive Control; Immunogen; SDS-PAGE; WB.
APC206Hu01 Active Histone Deacetylase 1 (HDAC1) Cell culture; Activity Assays.
Antibodies PAC206Hu01 Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu22 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC/IF;FCM
MAC206Hu21 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu23 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; IF
MAC206Hu24 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu25 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu26 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu27 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu28 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Hu29 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
Assay Kits SEC206Hu ELISA Kit for Histone Deacetylase 1 (HDAC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC206Mu01 Recombinant Histone Deacetylase 1 (HDAC1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC206Mu02 Recombinant Histone Deacetylase 1 (HDAC1) Positive Control; Immunogen; SDS-PAGE; WB.
APC206Mu01 Active Histone Deacetylase 1 (HDAC1) Cell culture; Activity Assays.
Antibodies PAC206Mu01 Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
PAC206Mu02 Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
Assay Kits SEC206Mu ELISA Kit for Histone Deacetylase 1 (HDAC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC206Ra01 Recombinant Histone Deacetylase 1 (HDAC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC206Ra01 Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
MAC206Ra21 Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) WB; IHC; ICC; IP.
Assay Kits SEC206Ra ELISA Kit for Histone Deacetylase 1 (HDAC1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p."Science 272:408-411(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae."Cytogenet. Cell Genet. 73:130-133(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "MEF-2 function is modified by a novel co-repressor, MITR."EMBO J. 18:5085-5098(1999) [PubMed] [Europe PMC] [Abstract]
  5. "BCoR, a novel corepressor involved in BCL-6 repression."Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
  6. "HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins."J. Biol. Chem. 275:27909-27916(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing."J. Biol. Chem. 275:40782-40787(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Sequestration and inhibition of Daxx-mediated transcriptional repression by PML."Mol. Cell. Biol. 20:1784-1796(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5."Proc. Natl. Acad. Sci. U.S.A. 97:1056-1061(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation."J. Biol. Chem. 276:47733-47741(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation."Genes Dev. 15:1140-1151(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1."J. Biol. Chem. 276:6817-6824(2001) [PubMed] [Europe PMC] [Abstract]
  13. "TGIF2 interacts with histone deacetylase 1 and represses transcription."J. Biol. Chem. 276:32109-32114(2001) [PubMed] [Europe PMC] [Abstract]
  14. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
  15. "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."EMBO J. 21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]
  16. "SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities."J. Biol. Chem. 277:23658-23663(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene."EMBO J. 22:6299-6309(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
  19. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Acetylated SP3 is a transcriptional activator."J. Biol. Chem. 278:35775-35780(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain."Mol. Cell. Biol. 23:250-258(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Identification and characterization of three new components of the mSin3A corepressor complex."Mol. Cell. Biol. 23:3456-3467(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein."Oncogene 22:2541-2547(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex."Biochem. Biophys. Res. Commun. 323:1216-1222(2004) [PubMed] [Europe PMC] [Abstract]
  25. "MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."Cell 119:75-86(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1."J. Biol. Chem. 279:41477-41486(2004) [PubMed] [Europe PMC] [Abstract]
  27. "SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1."Mol. Cell. Biol. 24:6021-6028(2004) [PubMed] [Europe PMC] [Abstract]
  28. "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain."Oncogene 23:7601-7610(2004) [PubMed] [Europe PMC] [Abstract]
  29. "NuRD and SIN3 histone deacetylase complexes in development."Trends Genet. 16:351-356(2000) [PubMed] [Europe PMC] [Abstract]
  30. "Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein."J. Biol. Chem. 280:28507-28518(2005) [PubMed] [Europe PMC] [Abstract]
  31. "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex."Mol. Cell. Biol. 25:8415-8429(2005) [PubMed] [Europe PMC] [Abstract]
  32. "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases."Biochem. J. 397:169-177(2006) [PubMed] [Europe PMC] [Abstract]
  33. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  34. "Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription."Mol. Cell. Biol. 26:1770-1785(2006) [PubMed] [Europe PMC] [Abstract]
  35. "Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis."Mol. Cell. Biol. 26:8683-8696(2006) [PubMed] [Europe PMC] [Abstract]
  36. "SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus."Nucleic Acids Res. 34:3288-3298(2006) [PubMed] [Europe PMC] [Abstract]
  37. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
  38. "Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1."FASEB J. 21:3386-3397(2007) [PubMed] [Europe PMC] [Abstract]
  39. "Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases."Int. J. Cancer 121:265-275(2007) [PubMed] [Europe PMC] [Abstract]
  40. "Regulation of E2F1 function by the nuclear corepressor KAP1."J. Biol. Chem. 282:29902-29909(2007) [PubMed] [Europe PMC] [Abstract]
  41. "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."J. Biol. Chem. 282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
  42. "Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation."Nucleic Acids Res. 35:1958-1968(2007) [PubMed] [Europe PMC] [Abstract]
  43. "SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1."Oncogene 26:5866-5876(2007) [PubMed] [Europe PMC] [Abstract]
  44. "The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter."Biochim. Biophys. Acta 1783:224-236(2008) [PubMed] [Europe PMC] [Abstract]
  45. "Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification."J. Biol. Chem. 283:5081-5089(2008) [PubMed] [Europe PMC] [Abstract]
  46. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  47. "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation."Mol. Cell 32:718-726(2008) [PubMed] [Europe PMC] [Abstract]
  48. "Protein lysine methyltransferase G9a acts on non-histone targets."Nat. Chem. Biol. 4:344-346(2008) [PubMed] [Europe PMC] [Abstract]
  49. "A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression."Neuron 60:775-787(2008) [PubMed] [Europe PMC] [Abstract]
  50. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  51. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  52. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  53. "SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells."J. Biol. Chem. 284:3334-3344(2009) [PubMed] [Europe PMC] [Abstract]
  54. "FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4."PLoS ONE 4:E5071-E5071(2009) [PubMed] [Europe PMC] [Abstract]
  55. "Chfr is linked to tumour metastasis through the downregulation of HDAC1."Nat. Cell Biol. 11:295-302(2009) [PubMed] [Europe PMC] [Abstract]
  56. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  57. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  58. "Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation." Nat. Cell Biol. 12:132-142(2010) [PubMed] [Europe PMC] [Abstract]
  59. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  60. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  61. "Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1."Mol. Cell 42:285-296(2011) [PubMed] [Europe PMC] [Abstract]
  62. "SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability."PLoS ONE 6:E23046-E23046(2011) [PubMed] [Europe PMC] [Abstract]
  63. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  64. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  65. "Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting."Nucleic Acids Res. 43:2033-2044(2015) [PubMed] [Europe PMC] [Abstract]