Allograft inflammatory factor 1 (AIF1)

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IBA1; IRT1; Daintain; Protein G1; Ionized calcium-binding adapter molecule 1; G1

Allograft inflammatory factor 1 (AIF1)

Allograft inflammatory factor 1 is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC288Hu01 Recombinant Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC288Hu02 Recombinant Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
APC288Hu61 Active Allograft inflammatory factor 1 (AIF1) Cell culture; Activity Assays.
Antibodies PAC288Hu01 Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB,IHC; FCM
MAC288Hu22 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
LAC288Hu71 Biotin-Linked Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC.
LAC288Hu81 FITC-Linked Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IF.
PAC288Hu02 Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
LAC288Hu72 Biotin-Linked Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC.
LAC288Hu82 FITC-Linked Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IF.
MAC288Hu21 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
MAC288Hu23 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
Assay Kits SEC288Hu ELISA Kit for Allograft inflammatory factor 1 (AIF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC288Hu CLIA Kit for Allograft inflammatory factor 1 (AIF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC288Mu01 Recombinant Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC288Mu02 Recombinant Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
EPC288Mu61 Eukaryotic Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC288Mu01 Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
LAC288Mu71 Biotin-Linked Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC.
PAC288Mu02 Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
Assay Kits SEC288Mu ELISA Kit for Allograft inflammatory factor 1 (AIF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC288Mu CLIA Kit for Allograft inflammatory factor 1 (AIF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC288Ra01 Recombinant Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC288Ra01 Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
LAC288Ra71 Biotin-Linked Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC.
MAC288Ra21 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB
LAC288Ra72 Biotin-Linked Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC.
MAC288Ra23 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
MAC288Ra24 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
MAC288Ra25 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
MAC288Ra22 Monoclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
Assay Kits SEC288Ra ELISA Kit for Allograft inflammatory factor 1 (AIF1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC288Ra CLIA Kit for Allograft inflammatory factor 1 (AIF1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Cavia (Guinea pig )

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC288Gu01 Recombinant Allograft inflammatory factor 1 (AIF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC288Gu01 Polyclonal Antibody to Allograft inflammatory factor 1 (AIF1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Allograft inflammatory factor 1 (AIF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Allograft inflammatory factor 1 (AIF1) ELISA Kit Customized Service Offer
  1. "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and genomic characterization of LST1: a new gene in the human TNF region."Immunogenetics 42:315-322(1995) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries."Biochem. Biophys. Res. Commun. 228:29-37(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts."Transplantation 61:1387-1392(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing."Genomics 45:591-600(1997) [PubMed] [Europe PMC] [Abstract]
  6. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF."Arterioscler. Thromb. Vasc. Biol. 24:1217-1222(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."Am. J. Pathol. 167:619-626(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Structural and functional characterization of human Iba proteins."FEBS J. 275:4627-4640(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."J. Mol. Biol. 364:449-457(2006) [PubMed] [Europe PMC] [Abstract]
  17. "NMR structure of the human allograft inflammatory factor 1."Submitted (FEB-2009) to the PDB data bank