Ionized Calcium-binding Adapter Molecule 1 (IBA1)
[Edit]AIF1; IRT1; Daintain; Protein G1; Allograft Inflammatory Factor 1
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Allograft inflammatory factor 1 is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC288Mu01 | Recombinant Ionized Calcium-binding Adapter Molecule 1 (IBA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPC288Mu02 | Recombinant Ionized Calcium-binding Adapter Molecule 1 (IBA1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPC288Mu61 | Eukaryotic Ionized Calcium-binding Adapter Molecule 1 (IBA1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAC288Mu01 | Polyclonal Antibody to Ionized Calcium-binding Adapter Molecule 1 (IBA1) | WB; IHC; ICC; IP. |
| LAC288Mu71 | Biotin-Linked Polyclonal Antibody to Ionized Calcium-binding Adapter Molecule 1 (IBA1) | WB; IHC; ICC. | |
| PAC288Mu02 | Polyclonal Antibody to Ionized Calcium-binding Adapter Molecule 1 (IBA1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC288Mu | ELISA Kit for Ionized Calcium-binding Adapter Molecule 1 (IBA1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCC288Mu | CLIA Kit for Ionized Calcium-binding Adapter Molecule 1 (IBA1) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC288Gu01 | Recombinant Ionized Calcium-binding Adapter Molecule 1 (IBA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC288Gu01 | Polyclonal Antibody to Ionized Calcium-binding Adapter Molecule 1 (IBA1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Ionized Calcium-binding Adapter Molecule 1 (IBA1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ionized Calcium-binding Adapter Molecule 1 (IBA1) | ELISA Kit Customized Service Offer |
- "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
- "Cloning and genomic characterization of LST1: a new gene in the human TNF region."Immunogenetics 42:315-322(1995) [PubMed] [Europe PMC] [Abstract]
- "cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries."Biochem. Biophys. Res. Commun. 228:29-37(1996) [PubMed] [Europe PMC] [Abstract]
- "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts."Transplantation 61:1387-1392(1996) [PubMed] [Europe PMC] [Abstract]
- "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing."Genomics 45:591-600(1997) [PubMed] [Europe PMC] [Abstract]
- "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF."Arterioscler. Thromb. Vasc. Biol. 24:1217-1222(2004) [PubMed] [Europe PMC] [Abstract]
- "Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."Am. J. Pathol. 167:619-626(2005) [PubMed] [Europe PMC] [Abstract]
- "Structural and functional characterization of human Iba proteins."FEBS J. 275:4627-4640(2008) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."J. Mol. Biol. 364:449-457(2006) [PubMed] [Europe PMC] [Abstract]
- "NMR structure of the human allograft inflammatory factor 1."Submitted (FEB-2009) to the PDB data bank