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Fibroblast Activation Protein Alpha (FAPa)

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APCE; SIMP; DPPIV; Seprase; 170 kDa melanoma membrane-bound gelatinase; Post-proline cleaving enzyme; Serine integral membrane protease; Surface-expressed protease

Fibroblast Activation Protein Alpha (FAPa)
CCC C469
HGNC 3590
MGI 109608
PubMed 11208014
RGD 621253
UniProt Q12884
Wiki FAPA

Fibroblast activation protein, alpha, also known as FAP, is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. FAP, also known as seprase, belongs to the clan SC proteases and is a member of the S9B prolyl oligopeptidase subfamily. Other members of the S9B subfamily are DPPIV, DPP8 and DPP9. FAP is most closely related to DPPIV and they share about 50% of there amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC469Hu01 Recombinant Fibroblast Activation Protein Alpha (FAPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC469Hu01 Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
MAC469Hu22 Monoclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB
MAC469Hu21 Monoclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
MAC469Hu23 Monoclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
MAC469Hu24 Monoclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) IHC
MAC469Hu25 Monoclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB
Assay Kits SEC469Hu ELISA Kit for Fibroblast Activation Protein Alpha (FAPa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC469Mu01 Recombinant Fibroblast Activation Protein Alpha (FAPa) Positive Control; Immunogen; SDS-PAGE; WB.
RPC469Mu02 Recombinant Fibroblast Activation Protein Alpha (FAPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC469Mu01 Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
PAC469Mu02 Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
Assay Kits SEC469Mu ELISA Kit for Fibroblast Activation Protein Alpha (FAPa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC469Ra01 Recombinant Fibroblast Activation Protein Alpha (FAPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC469Ra01 Polyclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
MAC469Ra21 Monoclonal Antibody to Fibroblast Activation Protein Alpha (FAPa) WB; IHC; ICC; IP.
Assay Kits SEC469Ra ELISA Kit for Fibroblast Activation Protein Alpha (FAPa) Enzyme-linked immunosorbent assay for Antigen Detection.
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  10. "A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells."Cancer Res. 54:5702-5710(1994) [PubMed] [Europe PMC] [Abstract]
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  19. "The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices."Cancer Res. 66:4652-4661(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity."FEBS Lett. 580:1581-1586(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity."J. Biol. Chem. 281:7437-7444(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization."Biochemistry 46:4598-4605(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites."Biochemistry 47:1076-1086(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Seprase: an overview of an important matrix serine protease."Biochim. Biophys. Acta 1784:1130-1145(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors."Biol. Chem. 392:199-207(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."FEBS J. 278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate."J. Biochem. 149:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs." FEBS Open Bio 4:43-54(2013) [PubMed] [Europe PMC] [Abstract]
  29. "A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation."Biochim. Biophys. Acta 1844:1248-1259(2014) [PubMed] [Europe PMC] [Abstract]
  30. "Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha."J. Biol. Chem. 280:19441-19444(2005) [PubMed] [Europe PMC] [Abstract]