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Hemopoietic Cell Kinase (HCK)

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JTK9; Hematopoietic cell kinase; p59-HCK/p60-HCK

Hemopoietic Cell Kinase (HCK)
CCC C522
HGNC 4840
MGI 96052
PubMed 3496523
RGD 2785
UniProt P08631
Wiki HCK
Tyrosine-protein kinase HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.HCK, the deduced amino acid sequence of the protein encoded by HCK, and the distribution of RNA transcribed from HCK among various hemopoietic cells.Since this region is affected by interstitial deletions in some acute myeloid leukemias and myeloproliferative disorders, they suggested that damage to HCK may contribute to the pathogenesis of these conditions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC522Hu01 Recombinant Hemopoietic Cell Kinase (HCK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC522Hu01 Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) WB; IHC; ICC; IP.
Assay Kits SEC522Hu ELISA Kit for Hemopoietic Cell Kinase (HCK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC522Mu01 Recombinant Hemopoietic Cell Kinase (HCK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC522Mu01 Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hemopoietic Cell Kinase (HCK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemopoietic Cell Kinase (HCK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hemopoietic Cell Kinase (HCK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hemopoietic Cell Kinase (HCK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hemopoietic Cell Kinase (HCK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hemopoietic Cell Kinase (HCK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemopoietic Cell Kinase (HCK) ELISA Kit Customized Service Offer
  1. "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells."Mol. Cell. Biol. 7:2267-2275(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin."Mol. Cell. Biol. 7:2276-2285(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization."Mol. Cell. Biol. 11:4363-4370(1991) [PubMed] [Europe PMC] [Abstract]
  7. "The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family."Gene 113:275-280(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells."J. Biol. Chem. 269:8878-8884(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn."J. Exp. Med. 180:1165-1170(1994) [PubMed] [Europe PMC] [Abstract]
  10. "The Fc gamma RI receptor signals through the activation of hck and MAP kinase."J. Immunol. 154:4039-4047(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae."Mol. Cell. Biol. 15:3507-3515(1995) [PubMed] [Europe PMC] [Abstract]
  12. "Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines."Exp. Hematol. 25:1367-1377(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Hck is activated by opsonized zymosan and A23187 in distinct subcellular fractions of human granulocytes."J. Biol. Chem. 272:102-109(1997) [PubMed] [Europe PMC] [Abstract]
  14. "SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1."J. Biol. Chem. 272:17899-17902(1997) [PubMed] [Europe PMC] [Abstract]
  15. "The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr."J. Biol. Chem. 272:33260-33270(1997) [PubMed] [Europe PMC] [Abstract]
  16. "The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase."Biochem. Biophys. Res. Commun. 257:129-138(1999) [PubMed] [Europe PMC] [Abstract]
  17. "IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck."J. Immunol. 164:4575-4585(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand."J. Biol. Chem. 275:2721-2726(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI."Nat. Immunol. 1:227-233(2000) [PubMed] [Europe PMC] [Abstract]
  20. "The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein."J. Biol. Chem. 276:16885-16893(2001) [PubMed] [Europe PMC] [Abstract]
  21. "The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK."J. Biol. Chem. 276:42389-42400(2001) [PubMed] [Europe PMC] [Abstract]
  22. "The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells."EMBO J. 21:5766-5774(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases."J. Biol. Chem. 277:4999-5007(2002) [PubMed] [Europe PMC] [Abstract]
  24. "p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner."J. Biol. Chem. 277:21007-21016(2002) [PubMed] [Europe PMC] [Abstract]
  25. "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation."Oncogene 21:1707-1716(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells."J. Biol. Chem. 279:21658-21665(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck."Biochemistry 44:8841-8849(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes."Traffic 6:682-694(2005) [PubMed] [Europe PMC] [Abstract]
  29. "HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction."J. Biol. Chem. 281:27029-27038(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Regulation of p73 by Hck through kinase-dependent and independent mechanisms."BMC Mol. Biol. 8:45-45(2007) [PubMed] [Europe PMC] [Abstract]
  31. "Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases."Oncogene 26:4987-4998(2007) [PubMed] [Europe PMC] [Abstract]
  32. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  33. "The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms."Eur. J. Cancer 45:321-327(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
  35. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  36. "c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration."FEBS Lett. 584:15-21(2010) [PubMed] [Europe PMC] [Abstract]
  37. "Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner."J. Biol. Chem. 285:21446-21457(2010) [PubMed] [Europe PMC] [Abstract]
  38. "Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis."Eur. J. Cell Biol. 87:527-542(2008) [PubMed] [Europe PMC] [Abstract]
  39. "Protein tyrosine kinases in neutrophil activation and recruitment."Arch. Biochem. Biophys. 510:112-119(2011) [PubMed] [Europe PMC] [Abstract]
  40. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  41. "Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK."Biomed. Rep. 3:9-13(2015) [PubMed] [Europe PMC] [Abstract]
  42. "Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase."FEBS Lett. 406:131-135(1997) [PubMed] [Europe PMC] [Abstract]
  43. "Crystal structure of the Src family tyrosine kinase Hck."Nature 385:602-609(1997) [PubMed] [Europe PMC] [Abstract]
  44. "RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef."Biochemistry 37:14683-14691(1998) [PubMed] [Europe PMC] [Abstract]
  45. "Solution structure of the human Hck SH3 domain and identification of its ligand binding site."J. Mol. Biol. 278:253-265(1998) [PubMed] [Europe PMC] [Abstract]
  46. "Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor."Mol. Cell 3:639-648(1999) [PubMed] [Europe PMC] [Abstract]
  47. "Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection."Bioorg. Med. Chem. Lett. 16:118-122(2006) [PubMed] [Europe PMC] [Abstract]
  48. "The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)."Bioorg. Med. Chem. Lett. 16:5973-5977(2006) [PubMed] [Europe PMC] [Abstract]
  49. "Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes."J. Mol. Biol. 365:1517-1532(2007) [PubMed] [Europe PMC] [Abstract]
  50. "Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism."J. Biol. Chem. 285:35455-35461(2010) [PubMed] [Europe PMC] [Abstract]
  51. "Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef."PLoS ONE 6:E20033-E20033(2011) [PubMed] [Europe PMC] [Abstract]
  52. "Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly."Traffic 12:867-877(2011) [PubMed] [Europe PMC] [Abstract]
  53. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]