Urocortin 2 (UCN2)

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URP; SRP; UCN-II; UCNII; Stresscopin-Related Peptide; Urocortin-related peptide

Urocortin 2 (UCN2)
Urocortin-2 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
Urocortin (UCN) II is a 38 amino acid member of the mammalian corticotropin-releasing hormone (CRH) peptide family, which also includes CRH, UCN I, and UCN III . CRH mainly binds to type 1 CRH receptors (CRH1), while UCN II and III bind primarily to type 2 CRH receptors, and UCN I binds to both (CRH2) .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC585Hu01 Recombinant Urocortin 2 (UCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC585Hu01 Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC
MAC585Hu22 Monoclonal Antibody to Urocortin 2 (UCN2) WB
LAC585Hu71 Biotin-Linked Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC.
LAC585Hu81 FITC-Linked Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IF.
LAC585Hu72 Biotin-Linked Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC.
MAC585Hu21 Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
MAC585Hu23 Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
MAC585Hu24 Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
MAC585Hu25 Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
MAC585Hu27 Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
Assay Kits SEC585Hu ELISA Kit for Urocortin 2 (UCN2) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC585Hu High Sensitive ELISA Kit for Urocortin 2 (UCN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC585Mu01 Recombinant Urocortin 2 (UCN2) Positive Control; Immunogen; SDS-PAGE; WB.
RPC585Mu02 Recombinant Urocortin 2 (UCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC585Mu01 Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
PAC585Mu02 Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
Assay Kits SEC585Mu ELISA Kit for Urocortin 2 (UCN2) Enzyme-linked immunosorbent assay for Antigen Detection.
CEC585Mu ELISA Kit for Urocortin 2 (UCN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC585Ra01 Recombinant Urocortin 2 (UCN2) Positive Control; Immunogen; SDS-PAGE; WB.
CPC585Ra21 OVA Conjugated Urocortin 2 (UCN2) Immunogen; SDS-PAGE; WB.
Antibodies PAC585Ra01 Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
MAC585Ra21 Monoclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
PAC585Ra08 Polyclonal Antibody to Urocortin 2 (UCN2) WB; IHC; ICC; IP.
Assay Kits SEC585Ra ELISA Kit for Urocortin 2 (UCN2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Posttranslational processing of human and mouse urocortin 2: characterization and bioactivity of gene products."Endocrinology 154:1553-1564(2013) [PubMed] [Europe PMC] [Abstract]
  4. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]