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Carbonic Anhydrase VII (CA7)

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CA-VII; CAVII; Carbonate dehydratase VII

Carbonic Anhydrase VII (CA7)
CCC D074
HGNC 1381
MGI 103100
PubMed 23881097
UniProt P43166
Wiki CA7
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.Montgomery et al. mapped the partially characterized CA7 isozyme to chromosome 16q21-q23 by analysis of somatic cell hybrids and by in situ hybridization. The mRNA for CA VII was detected only in salivary glands.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Carbonic Anhydrase VII (CA7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Carbonic Anhydrase VII (CA7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Carbonic Anhydrase VII (CA7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Carbonic Anhydrase VII (CA7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase VII (CA7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD074Mu01 Recombinant Carbonic Anhydrase VII (CA7) Positive Control; Immunogen; SDS-PAGE; WB.
APD074Mu01 Active Carbonic Anhydrase VII (CA7) Cell culture; Activity Assays.
Antibodies PAD074Mu01 Polyclonal Antibody to Carbonic Anhydrase VII (CA7) WB; IHC; ICC; IP.
LAD074Mu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase VII (CA7) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase VII (CA7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase VII (CA7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD074Ra01 Recombinant Carbonic Anhydrase VII (CA7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD074Ra01 Polyclonal Antibody to Carbonic Anhydrase VII (CA7) WB; IHC; ICC; IP.
LAD074Ra71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase VII (CA7) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Carbonic Anhydrase VII (CA7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Carbonic Anhydrase VII (CA7) ELISA Kit Customized Service Offer
  1. "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16."Genomics 11:835-848(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."Chemistry 12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."J. Med. Chem. 49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."Angew. Chem. Int. Ed. Engl. 46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."Bioorg. Med. Chem. Lett. 17:628-635(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human carbonic anhydrase VII [isoform 1], CA7."Submitted (JUN-2010) to the PDB data bank