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Hedgehog Homolog, Indian (IHH)

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BDA1; HHG2

Hedgehog Homolog, Indian (IHH)
CCC D116
HGNC 5956
MGI 96533
PubMed 19793350
RGD 620021
UniProt Q14623
Wiki IHH
IHH is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) and Sonic hedgehog (SHH). It is involved in chondrocyte differentiation, proliferation and maturation especially during endochondral ossification. It regulates its effects by feedback control of parathyroid hormone-related peptide (PTHrP).Gao et al. (2001) decided to focus on IHH as the gene implicated in brachydactyly type A1 because of its position in the implicated interval on chromosome 2q35-q36 flanked by markers D2S2248 and D2S360 and becauseIHH is known to mediate condensation, growth, and differentiation of cartilage. They identified 3 heterozygous missense mutations in the region encoding the amino-terminal signaling domain in all affected members of 3 large, unrelated Chinese families.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD116Hu01 Recombinant Hedgehog Homolog, Indian (IHH) Positive Control; Immunogen; SDS-PAGE; WB.
RPD116Hu02 Recombinant Hedgehog Homolog, Indian (IHH) Positive Control; Immunogen; SDS-PAGE; WB.
APD116Hu01 Active Hedgehog Homolog, Indian (IHH) Cell culture; Activity Assays.
Antibodies PAD116Hu01 Polyclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
LAD116Hu71 Biotin-Linked Polyclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC.
MAD116Hu21 Monoclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
PAD116Hu02 Polyclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
Assay Kits SED116Hu ELISA Kit for Hedgehog Homolog, Indian (IHH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD116Mu01 Recombinant Hedgehog Homolog, Indian (IHH) Positive Control; Immunogen; SDS-PAGE; WB.
RPD116Mu02 Recombinant Hedgehog Homolog, Indian (IHH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD116Mu01 Polyclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
PAD116Mu02 Polyclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
Assay Kits SED116Mu ELISA Kit for Hedgehog Homolog, Indian (IHH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD116Ra01 Recombinant Hedgehog Homolog, Indian (IHH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD116Ra01 Polyclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
MAD116Ra21 Monoclonal Antibody to Hedgehog Homolog, Indian (IHH) WB; IHC; ICC; IP.
Assay Kits SED116Ra ELISA Kit for Hedgehog Homolog, Indian (IHH) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Expression of Sonic hedgehog and its receptor Patched/Smoothened in human cancer cell lines and embryonic organs."J. Biochem. Mol. Biol. Biophys. 4:27-34(2000)
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog."Genomics 28:44-51(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Products, genetic linkage and limb patterning activity of a murine hedgehog gene."Development 120:3339-3353(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a palmitic acid-modified form of human Sonic hedgehog."J. Biol. Chem. 273:14037-14045(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."J. Biol. Chem. 285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels."Cell Res. 21:1343-1357(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1."Nat. Genet. 28:386-388(2001) [PubMed] [Europe PMC] [Abstract]
  10. "A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved."Hum. Genet. 111:368-375(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips."Am. J. Hum. Genet. 72:1040-1046(2003) [PubMed] [Europe PMC] [Abstract]