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Glycogen Synthase Kinase 3 Beta (GSK3b)

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Serine/threonine-protein kinase GSK3B

Glycogen Synthase Kinase 3 Beta (GSK3b)
CCC D317
HGNC 4617
MGI 1861437
PubMed 18852354
RGD 70982
UniProt P49841
Wiki GSK3B
Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation (Plyte et al., 1992). By Northern blot analysis, Lau et al. (1999) showed that GSK3B is predominantly expressed as 8.3- and 2.8-kb transcripts in testis, thymus, prostate, and ovary, but weakly expressed in lung and kidney. Western blot analysis revealed expression of a 46-kD protein in lung, kidney, and brain. By comparative analysis of various promoter constructs, Lau et al. (1999) observed that GSK3B expression is greater in neuronal than in kidney cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD317Hu01 Recombinant Glycogen Synthase Kinase 3 Beta (GSK3b) Positive Control; Immunogen; SDS-PAGE; WB.
APD317Hu01 Active Glycogen Synthase Kinase 3 Beta (GSK3b) Cell culture; Activity Assays.
Antibodies PAD317Hu01 Polyclonal Antibody to Glycogen Synthase Kinase 3 Beta (GSK3b) WB; IHC; ICC; IP.
MAD317Hu21 Monoclonal Antibody to Glycogen Synthase Kinase 3 Beta (GSK3b) WB; IHC; ICC; IP.
Assay Kits SED317Hu ELISA Kit for Glycogen Synthase Kinase 3 Beta (GSK3b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD317Mu01 Recombinant Glycogen Synthase Kinase 3 Beta (GSK3b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Glycogen Synthase Kinase 3 Beta (GSK3b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glycogen Synthase Kinase 3 Beta (GSK3b) Polyclonal Antibody Customized Service Offer
Assay Kits SED317Mu ELISA Kit for Glycogen Synthase Kinase 3 Beta (GSK3b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD317Ra01 Recombinant Glycogen Synthase Kinase 3 Beta (GSK3b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD317Ra01 Polyclonal Antibody to Glycogen Synthase Kinase 3 Beta (GSK3b) WB; IHC; ICC; IP.
MAD317Ra21 Monoclonal Antibody to Glycogen Synthase Kinase 3 Beta (GSK3b) WB; IHC; ICC; IP.
Assay Kits SED317Ra ELISA Kit for Glycogen Synthase Kinase 3 Beta (GSK3b) Enzyme-linked immunosorbent assay for Antigen Detection.
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