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Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2)

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Serine methylase; Glycine hydroxymethyltransferase

Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2)
CCC E217
HGNC 10852
MGI 1277989
PubMed 22461784
RGD 1308582
UniProt P34897
SHMT2 encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17.
Serine hydroxymethyltransferase is an enzyme which plays an important role in cellular one-carbon pathways by catalyzing the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and 5,6,7,8-tetrahydrofolate to 5,10-methylenetetrahydrofolate (hydrolysis).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE217Hu01 Recombinant Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE217Hu01 Polyclonal Antibody to Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) WB,IHC,ICC/IF; FCM
Assay Kits n/a CLIA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine Hydroxymethyltransferase 2, Mitochondrial (SHMT2) ELISA Kit Customized Service Offer
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  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of human mitochondrial serine hydroxymethyltransferase 2."Submitted (OCT-2010) to the PDB data bank