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Eukaryotic Translation Initiation Factor 4A1 (EIF4A1)

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DDX2A; EIF-4A; EIF4A; ATP-dependent RNA helicase eIF4A-1

Eukaryotic Translation Initiation Factor 4A1 (EIF4A1)
CCC F009
HGNC 3282
MGI 95303
PubMed 20156963
RGD 735141
UniProt P60842
Wiki EIF4A1
The eukaryotic initiation factor-4A family consists of 2 closely related genes, EIF4A1 and EIF4A2. These factors are required for the binding of mRNA to 40S ribosomal subunits. Nielsen et al. (1985) cloned eif4a1 cDNAs from mouse liver. They identified 2 distinct cDNAs differing in their untranslated regions. The sizes of these cDNAs correspond to 2 discrete mRNA bands of 2.0 and 1.6 kb seen on Northern blots of both mouse and human cells. Nielsen and Trachsel (1988) found that eif4a1 was expressed at similar levels in all mouse tissues examined, while eif4a2 had a much more varied pattern of expression. The EIF4A1 cDNA encodes a predicted 406-amino acid polypeptide with 92.7% amino acid similarity to the mouse protein. Kukimoto et al. (1997) characterized the promoter region of human EIF4A1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF009Hu01 Recombinant Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF009Hu01 Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI."Nucleic Acids Res. 21:2012-2012(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation."Nature 392:520-523(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."Mol. Cell. Biol. 20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo."J. Biol. Chem. 276:29111-29115(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Exportin 7 defines a novel general nuclear export pathway."EMBO J. 23:3227-3236(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia."Gene 347:137-145(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Cell stress modulates the function of splicing regulatory protein RBM4 in translation control."Proc. Natl. Acad. Sci. U.S.A. 104:2235-2240(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1."Proc. Natl. Acad. Sci. U.S.A. 107:2640-2645(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for translational inhibition by the tumour suppressor Pdcd4."EMBO J. 28:274-285(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the eIF4A-PDCD4 complex."Proc. Natl. Acad. Sci. U.S.A. 106:3148-3153(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative structural analysis of human DEAD-box RNA helicases."PLoS ONE 5:E12791-E12791(2010) [PubMed] [Europe PMC] [Abstract]