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Cold Inducible RNA Binding Protein (CIRBP)

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CIRP; A18HNRNP; Glycine-Rich RNA Binding Protein

Cold Inducible RNA Binding Protein (CIRBP)
CCC G886
HGNC 1982
MGI 893588
PubMed 23437386
RGD 620756
UniProt Q14011
Wiki CIRBP
Cold stress induces in microorganisms the synthesis of several proteins that are involved in various cellular processes such as transcription, translation, and recombination. The cold-inducible RNA-binding protein (Cirp) is induced in rodent cells by mild cold stress (32 degrees C). Cirp consists of an N-terminal RNA-binding domain and a C-terminal gly-rich domain, and plays an essential role in cold-induced suppression of cell proliferation.
CIRBP mRNA was constitutively expressed in all cell lines examined. In all of the cell lines, the levels of CIRBP mRNA and protein were increased within 12 hours after a temperature downshift from 37 degrees C to 32 degrees C. These results demonstrated that CIRBP is a cold-shock protein in human cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG886Hu01 Recombinant Cold Inducible RNA Binding Protein (CIRBP) Positive Control; Immunogen; SDS-PAGE; WB.
APG886Hu01 Active Cold Inducible RNA Binding Protein (CIRBP) Cell culture; Activity Assays.
Antibodies PAG886Hu01 Polyclonal Antibody to Cold Inducible RNA Binding Protein (CIRBP) WB,IHC,ICC/IF
MAG886Hu21 Monoclonal Antibody to Cold Inducible RNA Binding Protein (CIRBP) WB; IHC; ICC; IP.
Assay Kits SEG886Hu ELISA Kit for Cold Inducible RNA Binding Protein (CIRBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG886Mu01 Recombinant Cold Inducible RNA Binding Protein (CIRBP) Positive Control; Immunogen; SDS-PAGE; WB.
APG886Mu01 Active Cold Inducible RNA Binding Protein (CIRBP) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Cold Inducible RNA Binding Protein (CIRBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cold Inducible RNA Binding Protein (CIRBP) Polyclonal Antibody Customized Service Offer
Assay Kits SEG886Mu ELISA Kit for Cold Inducible RNA Binding Protein (CIRBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG886Ra01 Recombinant Cold Inducible RNA Binding Protein (CIRBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cold Inducible RNA Binding Protein (CIRBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cold Inducible RNA Binding Protein (CIRBP) Polyclonal Antibody Customized Service Offer
Assay Kits SEG886Ra ELISA Kit for Cold Inducible RNA Binding Protein (CIRBP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene."Gene 204:115-120(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein."J. Biol. Chem. 272:26720-26726(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response."J. Biol. Chem. 276:47277-47284(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism."J. Cell Sci. 117:1785-1794(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18."Nucleic Acids Res. 34:1224-1236(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of RRM domain in A18 HNRNP."Submitted (NOV-2005) to the PDB data bank