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p21 Protein Activated Kinase 4 (PAK4)

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Serine/threonine-protein kinase PAK 4

p21 Protein Activated Kinase 4 (PAK4)
CCC H464
HGNC 16059
MGI 1917834
PubMed 11413130
RGD 1307705
UniProt O96013
Wiki PAK4
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities.
PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Highest expression in prostate, testis and colon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH464Hu01 Recombinant p21 Protein Activated Kinase 4 (PAK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH464Hu01 Polyclonal Antibody to p21 Protein Activated Kinase 4 (PAK4) WB
MAH464Hu21 Monoclonal Antibody to p21 Protein Activated Kinase 4 (PAK4) WB; IHC; ICC; IP.
Assay Kits SEH464Hu ELISA Kit for p21 Protein Activated Kinase 4 (PAK4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCH464Hu CLIA Kit for p21 Protein Activated Kinase 4 (PAK4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH464Mu01 Recombinant p21 Protein Activated Kinase 4 (PAK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 4 (PAK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 4 (PAK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 4 (PAK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 4 (PAK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p21 Protein Activated Kinase 4 (PAK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p21 Protein Activated Kinase 4 (PAK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p21 Protein Activated Kinase 4 (PAK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p21 Protein Activated Kinase 4 (PAK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for p21 Protein Activated Kinase 4 (PAK4) ELISA Kit Customized Service Offer
  1. "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia."EMBO J. 17:6527-6540(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis."J. Biol. Chem. 276:14414-14419(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Activated PAK4 regulates cell adhesion and anchorage-independent growth."Mol. Cell. Biol. 21:3523-3533(2001) [PubMed] [Europe PMC] [Abstract]
  8. "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration."J. Cell Biol. 158:1287-1297(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4."Mol. Cell. Biol. 23:7838-7848(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin."EMBO J. 24:473-486(2005) [PubMed] [Europe PMC] [Abstract]
  11. "PAK4 mediates morphological changes through the regulation of GEF-H1."J. Cell Sci. 118:1861-1872(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration."J. Biol. Chem. 285:23699-23710(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis."J. Cell Biol. 190:807-822(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B."Mol. Biol. Cell 21:2996-3006(2010) [PubMed] [Europe PMC] [Abstract]
  20. "p21-activated kinases: three more join the Pak."Int. J. Biochem. Cell Biol. 34:713-717(2002) [PubMed] [Europe PMC] [Abstract]
  21. "The emerging importance of group II PAKs."Biochem. J. 425:465-473(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Crystal structure of the human p21-activated kinase 4."Submitted (JUL-2005) to the PDB data bank
  27. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]