≡

Guanylate Cyclase 1 Beta 3 (GUCY1b3)

[Edit]

GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; Soluble guanylate cyclase small subunit; Guanylate cyclase soluble subunit beta-3

Guanylate Cyclase 1 Beta 3 (GUCY1b3)
CCC H947
HGNC 4687
MGI 1860604
PubMed 24041655
RGD 2769
UniProt Q02153
Wiki GUCY1B3
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs.
NOGC had been considered a soluble enzyme, but evidence that the alpha-2 subunit of the alpha-2/beta-1 isoform interacts with the PDZ domain of PSD95 (DLG4) suggests that the alpha-2 subunit directs a membrane association of this isoform. The interaction with PSD95 locates the alpha-2/beta-1 isoform in close proximity to the NO-generating NO synthase (NOS1), thereby enabling the NO sensor to respond to locally raised NO concentrations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH947Hu01 Recombinant Guanylate Cyclase 1 Beta 3 (GUCY1b3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH947Hu21 Monoclonal Antibody to Guanylate Cyclase 1 Beta 3 (GUCY1b3) WB; IHC; ICC; IP.
PAH947Hu01 Polyclonal Antibody to Guanylate Cyclase 1 Beta 3 (GUCY1b3) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEH947Hu ELISA Kit for Guanylate Cyclase 1 Beta 3 (GUCY1b3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase 1 Beta 3 (GUCY1b3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase 1 Beta 3 (GUCY1b3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase 1 Beta 3 (GUCY1b3) Polyclonal Antibody Customized Service Offer
Assay Kits SEH947Mu ELISA Kit for Guanylate Cyclase 1 Beta 3 (GUCY1b3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase 1 Beta 3 (GUCY1b3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase 1 Beta 3 (GUCY1b3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase 1 Beta 3 (GUCY1b3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase 1 Beta 3 (GUCY1b3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase 1 Beta 3 (GUCY1b3) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain."FEBS Lett. 304:83-88(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Heterogeneity in human soluble guanylate cyclase due to alternative splicing."FEBS Lett. 290:157-158(1991) [PubMed] [Europe PMC] [Abstract]