Aortic Endothelial Cells (AEC)

The aorta is the body's largest artery, vertebrate circulation of the artery, it from the left ventricle, along the spine decreased, the blood from the heart is distributed to the body all the parts containing oxygenated blood from the heart is transported to various parts of the body. Located in the vascular wall of aortic endothelial cells (AEC) are often exposed to high blood pressure, which can induce endothelium derived substances which regulate vasoconstriction and vascular growth.

Aortic endothelial cells are also controlled by regulating the expression of cell adhesion molecules to fine tune the inflammatory response and fibrinolytic system. These physiological characteristics make the culture of the aortic endothelial cells are widely used in the mechanism of endothelial dysfunction, vascular disease and atherosclerosis pathogenesis and new disease treatment methods.