Liver-derived Mesenchymal Stem Cells (LMSCs)

Mesenchymal stem cells, or MSCs, are multipotent stromal cells that can differentiate into a variety of cell types, including: osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells). These properties, in combination with their developmental plasticity, have generated tremendous interest because of the potential use of MSC in regenerative medicine to replace damaged tissues.

Recent evidence highlights the therapeutic potential of mesenchymal stem cells for treatment of toxic liver injury, but whether MSC and their secreted factors stimulate liver regeneration after surgical injury remains unknown.Studies show that treatment with liver-derived mesenchymal stem cells，LMSCs-derived factors can promote hepatocyte proliferation and regenerative responses in the early phase after surgical resection. MSC may represent a feasible new strategy to promote liver regeneration in patients undergoing extensive liver resection or after transplantation of small liver grafts.