Bronchial Fibroblasts (BF)

Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of the easiest types of cells to grow in culture. Bronchial fibroblasts (BF) show a mesenchymal stem cell phenotype, mainly produce type III collagen, elastin and extracellular matrix protein. Bronchial fibroblasts play an important role in the process of repair and remodeling after injury. The accumulation of fibroblasts, which are located at the site of inflammation, is essential for effective repair after tissue damage. Inadequate or excessive accumulation of fibroblasts may lead to abnormal tissue function. Excessive fibroblast proliferation and collagen secretion can lead to the occurrence of bronchial epithelial fibrosis, resulting in airway obstruction and airway hyper responsiveness.