Coronary Artery Endothelial Cells (CAEC)

Vascular endothelial cells, which are composed of a layer of flat cells, between blood and blood vessels. They can process the metabolism of blood and tissue fluid exchange, and can synthesize and secrete a variety of bioactive substances, to ensure the normal vascular contraction and relaxation.

Coronary artery endothelial cells (CAEC) can synthesis of PGI2, and will increase PGI2 synthesis and release in myocardial ischemia, thus expanding coronary artery to regulate blood flow. Studies showed that angiotensin II upregulates oxidized LDL endothelial receptor LOX-1 gene expression and uptake of ox-LDL in human coronary artery endothelial cells. Coronary arter endothelial cells are also controlled by regulating the expression of cell adhesion molecules to control and fine tune the inflammatory response and fibrinolytic system. CAEC is widely used in the study of the mechanism of endothelial dysfunction and the pathogenesis and treatment of coronary heart disease and atherosclerosis.