Peripheral Blood Neutrophils (PBNs)

Neutrophils are kinds of highly versatile granulocytes, which constitutes 50–70% of all peripheral blood leucocytes in humans. After infection or tissue damage, Neutrophils can kill pathogens, release cytotoxic compounds and degradative enzymes, produce reactive oxygen species (ROS) and expel neutrophil extracellular traps (NETs). Inappropriate hyperactivation of neutrophils can lead to excessive inflammation and collateral injury to (healthy) tissue. Neutrophils are packed with pre‐made inflammatory mediators, including serine protease neutrophil elastase and neutrophil gelatinase or matrix metalloproteinase‐9 (MMP‐9).