CTLL-2 T-Lymphocytes (CTLL-2)

CTLL2 cell line is a cytotoxic T-lymphocyte (CTL) line that was derived from long-term culture of splenocytes isolated from a C57BL/6 mouse. CTLL2 cells are IL-2-dependent and exhibit phenotypic and functional characteristics of activated cytotoxic T cells. These cells are commonly used in immunology research to study T cell activation, proliferation, and cytotoxicity.

CTLL2 cells are a valuable tool for investigating the mechanisms of T cell-mediated immune responses, including antigen recognition, T cell receptor signaling, and effector functions such as cytokine production and cytotoxicity. Researchers use the CTLL2 cell line to study various aspects of T cell biology, immune regulation, and immune responses to infections, tumors, and autoimmunity.

Additionally, CTLL2 cells are often employed in assays to assess the cytotoxic activity of immune cells, screen immunomodulatory compounds, and evaluate the efficacy of immunotherapies targeting T cell functions. The unique characteristics of the CTLL2 cell line make it a useful model system for studying T cell biology and immunology in both basic research and preclinical studies aimed at developing new immunotherapies for cancer and other diseases.